{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:58:00Z","timestamp":1787320680203,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H040001"],"award-info":[{"award-number":["LY19H040001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,6,18]]},"abstract":"\n Testicular torsion\/detorsion-induced damage is considered as a typical ischemia-reperfusion injury attributed to excessive reactive oxygen species (ROS) production. ROS may regulate many genes whose expression affects cell-cycle regulation, cell proliferation, and apoptosis. The cAMP-responsive element modulator-\n \u03c4<\/jats:italic>\n (CREM\n \u03c4<\/jats:italic>\n ) gene expression in the testis is essential for normal germ cell differentiation. The present study was aimed at investigating the effect of sesamol, a powerful antioxidant, on testicular ischemia-reperfusion injury and related mechanisms in an experimental testicular torsion-detorsion rat model. The type of our study was a randomized controlled trial. Sixty rats were randomly divided into the following 3 groups: (1) sham-operated control group (\n \n n<\/mml:mi>\n =<\/mml:mo>\n 20<\/mml:mn>\n <\/mml:math>\n ), (2) testicular ischemia-reperfusion group (\n \n n<\/mml:mi>\n =<\/mml:mo>\n 20<\/mml:mn>\n <\/mml:math>\n ), and (3) testicular ischemia-reperfusion+sesamol-treated group (\n \n n<\/mml:mi>\n =<\/mml:mo>\n 20<\/mml:mn>\n <\/mml:math>\n ). Testicular ischemia-reperfusion was induced by left testicular torsion (720\u00b0 rotation in a counterclockwise direction) for 2 hours, followed by detorsion. Orchiectomy was performed at 4 hours or 3 months after detorsion. The testis was obtained for the analysis of the following parameters, including malondialdehyde level (a sensitive indicator of ROS), CREM\n \u03c4<\/jats:italic>\n expression, and spermatogenesis. In the testicular ischemia-reperfusion group, the malondialdehyde level was significantly increased with a concomitant significant decrease in CREM\n \u03c4<\/jats:italic>\n expression and spermatogenesis in ipsilateral testis. These results suggest that overproduction of ROS after testicular ischemia-reperfusion may downregulate CREM\n \u03c4<\/jats:italic>\n expression, which causes spermatogenic injury. Sesamol treatment resulted in a significant reduction in the malondialdehyde level and significant increase in CREM\n \u03c4<\/jats:italic>\n expression and spermatogenesis in ipsilateral testis. These data support the above suggestion. Our study shows that sesamol can attenuate testicular ischemia-reperfusion injury through scavenging ROS and upregulating CREM\n \u03c4<\/jats:italic>\n expression.\n <\/jats:p>","DOI":"10.1155\/2020\/9043806","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T19:33:03Z","timestamp":1592508783000},"page":"1-9","source":"Crossref","is-referenced-by-count":21,"title":["Sesamol Protects Testis from Ischemia-Reperfusion Injury through Scavenging Reactive Oxygen Species and Upregulating CREM\n \u03c4<\/i>\n Expression"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-7110","authenticated-orcid":true,"given":"Si-Ming","family":"Wei","sequence":"first","affiliation":[{"name":"Shulan International Medical College, Zhejiang Shuren University, Hangzhou City, Zhejiang Province 310015, China"},{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province 310053, 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