{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:04:57Z","timestamp":1780506297269,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571181"],"award-info":[{"award-number":["31571181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    This study was to explore the therapeutic effect and mechanism of the traditional Chinese medicine with the formula Da\u2010Cheng\u2010Qi\u2010Tang (T\u2010DCQT) and a modified Da\u2010Cheng\u2010Qi\u2010Tang (M\u2010DCQT) in a postoperative ileus (POI) mouse model. POI was induced via small bowel manipulation, and T\u2010DCQT or M\u2010DCQT was given by enema. The intestinal motility was measured with a charcoal mixture gavage. The intestinal tissues were collected for further studies by histopathological, qPCR, immunohistochemical staining, and Western blotting. Levels of inflammatory cytokines in blood were determined using a high\u2010throughput liquid chip. We found that gastrointestinal dysfunction was alleviated after administration of either a T\u2010DCQT or M\u2010DCQT enema. Increased expression of NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B, p38 MAPK, and TLR4 in the intestinal tissues of POI mice were reversed following treatment. IL\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, MIP\u20101\n                    <jats:italic>\u03b2,<\/jats:italic>\n                    and IL\u201017 levels were significantly reduced at 24\u2009h and 48\u2009h following treatment, while the MCP\u20101 level was only observed to be reduced at 24\u2009h after the treatment. Furthermore, compared with the T\u2010DCQT effect, M\u2010DCQT treatment was more effective in alleviating the increased IL\u20106, MIP\u20101\n                    <jats:italic>\u03b2,<\/jats:italic>\n                    and IL\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    levels. So, we draw a conclusion that T\u2010DCQT or M\u2010DCOT could ameliorate the POI\u2010associated inflammatory response and improve GI motility in a POI mouse model.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9074069","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T19:36:38Z","timestamp":1596224198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Traditional Chinese Medicine Da\u2010Cheng\u2010Qi\u2010Tang Ameliorates Impaired Gastrointestinal Motility and Intestinal Inflammatory Response in a Mouse Model of Postoperative Ileus"],"prefix":"10.1155","volume":"2020","author":[{"given":"Chunqiu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-349X","authenticated-orcid":false,"given":"Yongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12157"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1005833"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_108"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd004930.pub3"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9610(01)00781-4"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1987396"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9751-2"},{"key":"e_1_2_11_8_2","first-page":"20302","article-title":"Interventional effects of da-cheng-qi decoction on enteric nerve system in a rat model of multiple organ dysfunction syndrome","volume":"8","author":"Xie M. 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