{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:00:57Z","timestamp":1764194457512,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Provinical Administration of Traditional Chinese Medicine","award":["2015028","G2018041","19277779D"],"award-info":[{"award-number":["2015028","G2018041","19277779D"]}]},{"name":"Medical Application Technology Tracking Project of Hebei Province","award":["2015028","G2018041","19277779D"],"award-info":[{"award-number":["2015028","G2018041","19277779D"]}]},{"name":"Key Research and Development Program of Hebei Province","award":["2015028","G2018041","19277779D"],"award-info":[{"award-number":["2015028","G2018041","19277779D"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The liver is the only visceral organ that exhibits a remarkable capability of regenerating in response to partial hepatectomy (PH) or chemical injury. Improving liver regeneration (LR) ability is the basis for the favourable treatment outcome of patients after PH, which can serve as a potential indicator for postoperative survival. The present study aimed to investigate the protective effects of Yiqi Huoxue recipe (YQHX) on LR after PH in rats and further elucidate its underlying mechanism. A two\u2010thirds PH rat model was used in this study. Wistar rats were randomly divided into four groups: sham\u2010operated, PH, YQHX\u2009+\u2009PH, and Fuzheng Huayu decoction (FZHY)\u2009+\u2009PH groups. All rats were sacrificed under anesthesia at 24 and 72\u2009h after surgery. The rates of LR were calculated, and the expression levels of cyclin D1 and c\u2010jun were determined by immunohistochemical staining. The protein levels of p\u2010JNK1\/2, JNK1\/2, p\u2010c\u2010jun, c\u2010jun, Bax, and Bcl\u20102 were detected by Western blotting, while the mRNA levels of JNK1, JNK2, c\u2010jun, Bax, and Bcl\u20102 were examined by real\u2010time polymerase chain reaction (RT\u2010PCR). At the corresponding time points, YQHX and FZHY administration dramatically induced the protein levels of p\u2010JNK1\/2 compared to the PH group (<jats:italic>p<\/jats:italic> &lt; 0.05), while FZHY\u2009+\u2009PH group showed prominently increase in p\u2010JNK1\/2 protein levels compared to the YQHX\u2009+\u2009PH group (<jats:italic>p<\/jats:italic> &lt; 0.05). A similar trend was observed for the expression levels of p\u2010c\u2010jun. Compared to the PH group, YQHX and FZHY markedly reduced the mRNA and protein expression levels of Bax at 24\u2009h after PH, while those in the FZHY\u2009+\u2009PH group decreased more obviously (<jats:italic>p<\/jats:italic> &lt; 0.05). Besides, in comparison with the PH group, YQHX and FZHY administration predominantly upregulated the mRNA and protein expression levels of Bcl\u20102 at 24 and 72\u2009h after PH (<jats:italic>p<\/jats:italic> &lt; 0.05). In conclusion, YQHX improves LR in rats after PH by inhibiting hepatocyte apoptosis via the JNK signaling pathway.<\/jats:p>","DOI":"10.1155\/2020\/9085801","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:35:45Z","timestamp":1588030545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Yiqi Huoxue Recipe Improves Liver Regeneration in Rats after Partial Hepatectomy via JNK Pathway"],"prefix":"10.1155","volume":"2020","author":[{"given":"Wen-cong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-xian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-guang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-2814","authenticated-orcid":false,"given":"Yu-guo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-099X","authenticated-orcid":false,"given":"Yue-min","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090675"},{"key":"e_1_2_10_2_2","first-page":"186","article-title":"Experimental pathology of the liver: I. 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