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neurological attacks. Parishin A and isorhynchophylline (PI) is the active monomer component extracted from the traditional antimigraine Chinese medicinal combination of Gastrodia and Uncaria, respectively. In this study, using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS\/MS) technology, we performed pharmacokinetic and lipidomic study on migraine model rats after administration of PI. For the detection of the compounds in plasma, AB Sciex Triple Quad\u2122 4500 was applied for quantitative analysis, and the COSMOSIL C<jats:sub>18<\/jats:sub>column (2.1\u2009\u00d7\u2009100\u2009mm, 2.6\u2009<jats:italic>\u03bc<\/jats:italic>m) was used for separation. Isorhynchophylline (ISO:<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic>384.8\u2013241.2) and its main metabolite rhynchophylline (RHY:<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic>384.8\u2013160.2) were simultaneously detected under positive ion modes. Besides, parishin A (PA:<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic>995.1\u2013726.9) and its main metabolite gastrodin (GAS:<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic>331.1\u2013123.0) were simultaneously detected with negative ion modes. For the analysis of endogenous lipid components, Dionex Ultimate 3000 (UHPLC) Thermo Orbitrap Elite was applied for the detection, and the Waters UPLCRBEH C<jats:sub>18<\/jats:sub>column (1.7\u2009<jats:italic>\u03bc<\/jats:italic>m 100\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>\u2217<\/mml:mi><\/mml:math>\u20092.1\u2009mm) was used for separation. Chloroform\/methanol (2\u2009:\u20091,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>v<\/mml:mi><\/mml:math>\u2009:\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>v<\/mml:mi><\/mml:math>) was used for extraction. The results demonstrated that PI exists significant difference in metabolism between single- and coadministration and can regulate lipid levels associated with migraine.<\/jats:p>","DOI":"10.1155\/2020\/9101598","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:31:45Z","timestamp":1594078305000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetic and Lipidomic Assessment of the In Vivo Effects of Parishin A-Isorhynchophylline in Rat Migraine Models"],"prefix":"10.1155","volume":"2020","author":[{"given":"Chaoqun","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangxi University of Traditional Chinese Medicine, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhen","family":"He","sequence":"additional","affiliation":[{"name":"Jiangxi University of Traditional Chinese Medicine, Nanchang, China"},{"name":"State Key Laboratory of Innovative Drug and Efficient 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