{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:02:23Z","timestamp":1773252143140,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873234"],"award-info":[{"award-number":["81873234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273666"],"award-info":[{"award-number":["81273666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2018J01875"],"award-info":[{"award-number":["2018J01875"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Erchen decoction (ECD) is a common treatment prescribed in traditional Chinese medicine (TCM) clinics, which has remarkable efficacy in the treatment of obesity, fatty liver, hyperlipidemia, diabetes, and other diseases caused by phlegm. In this study, we investigated the effect that ECD had on the lipid metabolism induced by high\u2010fat diet in C57BL\/6 mice. Body weight, body length, and abdominal circumference were detected. Blood lipid content was measured via biochemical assay kit. The gene and protein expression of PPAR<jats:italic>\u03b3<\/jats:italic> and LPL in visceral fat and skeletal muscle of mice was measured by real\u2010time PCR and western blot. The research discovered that the phlegm\u2010resolving effect that ECD had on high\u2010fat diet mice was mainly manifested as reduced body weight, Lee\u2019s index, abdominal circumference, and level of TG and TC. Meanwhile, we observed significantly increased PPAR<jats:italic>\u03b3<\/jats:italic> mRNA and protein level in visceral fat and PPAR<jats:italic>\u03b3<\/jats:italic> and LPL protein level in skeletal muscle in the ECD group. Contrarily, a decrease in PPAR<jats:italic>\u03b3<\/jats:italic> mRNA level in skeletal muscle in the ECD group was observed. Therefore, we speculate that ECD regulates the lipid metabolic disorder by decreasing the blood lipid level. Moreover, the potential molecular mechanism of ECD is to promote the expression of PPAR<jats:italic>\u03b3<\/jats:italic> in visceral fat and skeletal muscle and the expression of LPL in skeletal muscle.<\/jats:p>","DOI":"10.1155\/2020\/9102475","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T23:38:37Z","timestamp":1583883517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPAR<i>\u03b3<\/i> and LPL Gene in a High\u2010Fat Diet C57BL\/6 Mice Model"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-6580","authenticated-orcid":false,"given":"Mengting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-4833","authenticated-orcid":false,"given":"Yanfei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-7761","authenticated-orcid":false,"given":"Bizhen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-4267","authenticated-orcid":false,"given":"Jicheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-0988","authenticated-orcid":false,"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-5278","authenticated-orcid":false,"given":"Yujie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-2476","authenticated-orcid":false,"given":"Shanshan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_10_1_2","article-title":"Pathological factors of obesity and its correlation with serum adipokines","volume":"12","author":"Linghong Liao C. 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