{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:57:41Z","timestamp":1787068661642,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MUC 111 project","award":["2018CXTD03"],"award-info":[{"award-number":["2018CXTD03"]}]},{"name":"MUC 111 project","award":["7182092"],"award-info":[{"award-number":["7182092"]}]},{"name":"MUC 111 project","award":["81703492"],"award-info":[{"award-number":["81703492"]}]},{"name":"Minzu University Research Fund","award":["2018CXTD03"],"award-info":[{"award-number":["2018CXTD03"]}]},{"name":"Minzu University Research Fund","award":["7182092"],"award-info":[{"award-number":["7182092"]}]},{"name":"Minzu University Research Fund","award":["81703492"],"award-info":[{"award-number":["81703492"]}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2018CXTD03"],"award-info":[{"award-number":["2018CXTD03"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7182092"],"award-info":[{"award-number":["7182092"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["81703492"],"award-info":[{"award-number":["81703492"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018CXTD03"],"award-info":[{"award-number":["2018CXTD03"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["7182092"],"award-info":[{"award-number":["7182092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703492"],"award-info":[{"award-number":["81703492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,9,9]]},"abstract":"\n Huntington\u2019s disease (HD) is a hereditary autosomal dominant neurodegenerative disease. Although studies have shown that blood oxidative stress markers are dysregulated in HD patients, clinical data on the blood oxidative stress markers of HD patients is inconsistent. To better understand the pathogenesis of HD, we performed a systematic review and meta-analysis of blood oxidative stress markers in HD patients and healthy control (HC) subjects. A database search from PubMed and Web of Science identified 12 studies with 375 HD patients and 447 HC subjects in this meta-analysis. A random-effects meta-analysis showed that blood lipid peroxidation products (Hedges\u2019\n \n g<\/mml:mi>\n =<\/mml:mo>\n 0.883<\/mml:mn>\n <\/mml:math>\n ,\n \n 95<\/mml:mn>\n %<\/mml:mi>\n CI<\/mml:mtext>\n =<\/mml:mo>\n 0.637<\/mml:mn>\n \u2009<\/mml:mtext>\n to<\/mml:mtext>\n \u2009<\/mml:mtext>\n 1.130<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ), 8-hydroxyguanosine (Hedges\u2019\n \n g<\/mml:mi>\n =<\/mml:mo>\n 1.727<\/mml:mn>\n <\/mml:math>\n ,\n \n 95<\/mml:mn>\n %<\/mml:mi>\n CI<\/mml:mtext>\n =<\/mml:mo>\n 0.489<\/mml:mn>\n \u2009<\/mml:mtext>\n to<\/mml:mtext>\n \u2009<\/mml:mtext>\n 2.965<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.006<\/mml:mn>\n <\/mml:math>\n ) levels, and the activity of glutathione peroxidase (Hedges\u2019\n \n g<\/mml:mi>\n =<\/mml:mo>\n 2.026<\/mml:mn>\n <\/mml:math>\n ,\n \n 95<\/mml:mn>\n %<\/mml:mi>\n CI<\/mml:mtext>\n =<\/mml:mo>\n 0.570<\/mml:mn>\n \u2009<\/mml:mtext>\n to<\/mml:mtext>\n \u2009<\/mml:mtext>\n 3.482<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.006<\/mml:mn>\n <\/mml:math>\n ) were significantly increased in HD patients compared to controls. In contrast, reduced glutathione levels were lower in HD patients than in controls (Hedges\u2019\n \n g<\/mml:mi>\n =<\/mml:mo>\n \u2212<\/mml:mo>\n 0.611<\/mml:mn>\n <\/mml:math>\n ,\n \n 95<\/mml:mn>\n %<\/mml:mi>\n CI<\/mml:mtext>\n =<\/mml:mo>\n \u2212<\/mml:mo>\n 1.016<\/mml:mn>\n \u2009<\/mml:mtext>\n to<\/mml:mtext>\n \u2212<\/mml:mo>\n 0.207<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.003<\/mml:mn>\n <\/mml:math>\n ). However, blood superoxide dismutase, cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides did not show significant differences between cases and controls. Taken together, this study clarified the associations between blood oxidative stress markers and HD, supporting the clinical evidence that HD is accompanied by increased oxidative stress.\n <\/jats:p>","DOI":"10.1155\/2020\/9187195","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T19:31:58Z","timestamp":1599679918000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["Blood Oxidative Stress Marker Aberrations in Patients with Huntington\u2019s Disease: A Meta-Analysis Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Quan","family":"Tang","sequence":"first","affiliation":[{"name":"Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-4408","authenticated-orcid":true,"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnomedicine for Ministry of Education, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, 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