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We investigated the effects of chaiqin chengqi decoction (CQCQD) on the CPI\u201017\/MLCP pathway in the small intestinal smooth muscle cells (SMCs) and strips (SMS) in an AP model. Necrotising AP was induced in rats by intraperitoneal injections (IPI) of L\u2010ornithine (3.0\u2009g\/kg, pH 7.0; hourly\u2009\u00d7\u20092) at 1 hour apart; controls received saline. In treatment groups, carbachol (CCh; 60\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/kg, IPI) or CQCQD (20\u2009g\/kg; 2\u2010hourly\u2009\u00d7\u20093, intragastric) was administered. The necrotising AP model was associated with systemic inflammation (serum IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) and worsened jejunum histopathology and motility (serum vasoactive intestinal peptide and intestinal fatty acid\u2010binding protein) as the disease progressed. There was decreased intracellular calcium concentration ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    ) SMCs. Contractile function of isolated SMCs was reduced and associated with down\u2010regulated expression of key mRNAs and proteins of the CPI\u201017\/MLCP pathway as well as increased IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    . CQCQD and CCh significantly reversed these changes and the disease severity. These data suggest that CQCQD can improve intestinal motility by modulating the CPI\u201017\/MLCP pathway in small intestinal smooth muscle during AP.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9189457","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T18:32:34Z","timestamp":1581359554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI\u201017\/MLCP Pathway Using Chaiqin Chengqi 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