{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:06:49Z","timestamp":1790996809444,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801732"],"award-info":[{"award-number":["81801732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","award":["81801732"],"award-info":[{"award-number":["81801732"]}],"id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT). Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT. However, the underlying mechanisms have not been well determined. Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients. <jats:italic>Methods<\/jats:italic>. Forty euthyroid patients with AIT were randomized into two groups. Group I was treated with 200\u2009<jats:italic>\u03bc<\/jats:italic>g\/day selenium supplementation, and group II received a placebo over a 3-month period. Thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were measured before and 3 months after treatments. Additionally, twenty healthy volunteers also served as a control group for the evaluation of such parameters in basic condition. <jats:italic>Results<\/jats:italic>. Totally, 32 patients (group I, <jats:italic>n<\/jats:italic>\u2009=\u200918; group II, <jats:italic>n<\/jats:italic>\u2009=\u200914) completed the clinical study and were incorporated into the statistics. MDA level was higher and SOD activity and TAC were lower in patients compared to healthy individuals. After 3 months, TPOAb titer significantly decreased within group I (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) but did not change within group II (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). There were also no statistically significant changes in TSH and TgAb titers within the two groups (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Additionally, decreased MDA level (from 6.8\u2009\u00b1\u20091.3\u2009nmol\/ml to 4.9\u2009\u00b1\u20090.7\u2009nmol\/ml; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and increased TAC (from 10.0\u2009\u00b1\u20091.9\u2009mmol\/l to 12.9\u2009\u00b1\u20093.1\u2009mmol\/l; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) and SOD activity (from 72.3\u2009\u00b1\u200910.3\u2009U\/ml to 84.3\u2009\u00b1\u200913.2\u2009U\/ml; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) were simultaneously observed after 3 months\u2019 selenium treatment. Moreover, there was a negative correlation between TAC and TgAb\/TPOAb and a positive correlation between MDA and TgAb\/TPOAb in AIT patients. <jats:italic>Conclusions<\/jats:italic>. Our findings support the hypothesis that selenium treatment could decrease TPOAb titer via enforcing the defense against oxidative stress in euthyroid patients with AIT, which may be a potential underlying mechanism.<\/jats:p>","DOI":"10.1155\/2020\/9210572","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T23:49:23Z","timestamp":1593560963000},"page":"1-7","source":"Crossref","is-referenced-by-count":27,"title":["Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xun","family":"Tian","sequence":"first","affiliation":[{"name":"Tianjin Institute of Hepatology, Tianjin Second People\u2019s Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Medical 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