{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:03:29Z","timestamp":1778162609102,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"science and technology project of XuZhou","award":["KC18033"],"award-info":[{"award-number":["KC18033"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To evaluate the plasma levels of lnc\u2010DC in primary Sj\u00f6gren\u2019s syndrome (pSS) patients and investigate the potential associations between lnc\u2010DC and disease activity.\n                    <jats:italic>Methods<\/jats:italic>\n                    . In this study, we recruited 358 enrollments, including 127 pSS patients without immune thrombocytopenia (ITP), 22 pSS patients with ITP, 50 systemic lupus erythematosus (SLE) patients, and 50 patients with rheumatoid arthritis (RA) and 109 healthy individuals, from Xuzhou Central Hospital. The expression of anti\u2010SSA and anti\u2010SSB was detected by enzyme\u2010linked immunosorbent assay (ELISA). Spearman rank correlation test was used to analyze the relationship between lnc\u2010DC and pSS activity. pSS activity was measured by anti\u2010SSA, anti\u2010SSB antibody, erythrocyte sedimentation rate (ESR), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    \u2010microglobulin levels. The receiver operating characteristic (ROC) curve was used to determine the diagnostic performance of plasma lnc\u2010DC for pSS.\n                    <jats:italic>Results<\/jats:italic>\n                    . Compared with healthy controls, SLE and RA patients, the lnc\u2010DC expression levels were significantly elevated in pSS patients (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), especially in pSS patients with ITP (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). As expected, we also found that the lnc\u2010DC expression positively correlated with anti\u2010SSA (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.290,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), anti\u2010SSB (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.172,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), ESR level (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.076,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    \u2010microglobulin level (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.070,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003) in pSS patients. ROC curves showed that plasma lnc\u2010DC in pSS patients had an AUC 0.80 with a sensitivity of 0.75 and specificity of 0.85 at the optimum cutoff 1.06 in discriminating SLE and RA patients. In addition, the combination of lnc\u2010DC and anti\u2010SSA\/SSB (AUC: 0.84, sensitivity: 0.79, specificity: 0.90) improved significantly the diagnostic ability of pSS patients from SLE and RA patients. In the efficacy monitoring study, levels of plasma lnc\u2010DC were dramatically decreased after treatment (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . These findings highlight that plasma lnc\u2010DC as a novel biomarker for the diagnosis of pSS and can be used to evaluate the therapeutic efficacy of pSS underwent interventional therapy.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9236234","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T15:35:05Z","timestamp":1602862505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of Long Noncoding RNAs lnc\u2010DC in Plasma as a New Biomarker for Primary Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yanhong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Zu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DeLiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-8166","authenticated-orcid":false,"given":"Guoping","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328350f95b"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8449-4"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000257"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.06.015"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.007"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.004"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.55"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075013"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312438630"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033100"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138341"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-017-0613-6"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.848"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.018"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.621"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.022"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.268953"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.26405"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304296"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.303123"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251456"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150121"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303915"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2934"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110619"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-442392"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.01010-13"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9748"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0188-9"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-019-00705-z"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01711"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8550-y"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.296"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15156-4"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23343"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.230359"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9236234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9236234.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/9236234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:19:20Z","timestamp":1762093160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/9236234"}},"subtitle":[],"editor":[{"given":"Dawei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/9236234"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9236234","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9236234"}}