{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:18:09Z","timestamp":1753881489867,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871145"],"award-info":[{"award-number":["81871145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Decidualization of ectopic endometrium often leads to the extensive proliferation of local tissue and is easily misdiagnosed as malignant tumors. The study is aimed at constructing a microRNA\u2010 (miRNA\u2010) mRNA network underlying decidualized endometriotic cyst stromal cells (ECSCs). <jats:italic>Methods<\/jats:italic>. All data were collected from the Gene Expression Omnibus (GEO) database. Firstly, the differentially expressed genes (DEGs, adj. <jats:italic>P<\/jats:italic>\u2010Val &lt; 0.05, | log FC |\u2009\u22651) and miRNAs (DEMs, <jats:italic>P<\/jats:italic>\u2010Val &lt; 0.05, \u2223log\u2009FC | \u22651) were analyzed by the <jats:italic>limma<\/jats:italic> package. Secondly, we predicted the target genes (TGs) of these DEMs through the TargetScan, miRDB, and miRTarBase databases. The overlapping genes between DEGs and TGs were screened out. Thirdly, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses of the overlapping genes were performed for integrated discovery, visualization, and annotation. Then, the protein\u2010protein interaction (PPI) network of the overlapping genes was conducted by the STRING database. Finally, we combined the PPI network and the miRNA\u2010mRNA pairs to build a miRNA\u2010mRNA network. <jats:italic>Results<\/jats:italic>. There are 29 DEMs and 523 DEGs. Fourteen overlapping genes were screened out, and these genes were significantly enriched in metabolism and immunity. What is more, a miRNA\u2010mRNA network, including 14 mRNAs and 9 miRNAs, was successfully constructed. <jats:italic>Conclusions<\/jats:italic>. Taken together, the miRNA\u2010mRNA regulatory networks described in this study may provide new insights in the decidualization of ECSCs, suggesting further investigations in novel pathogenic mechanisms.<\/jats:p>","DOI":"10.1155\/2020\/9246868","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T23:41:48Z","timestamp":1597880508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Construction of a MicroRNA\u2010mRNA Network Underlying Decidualized Endometriotic Cyst Stromal Cells Using Bioinformatics 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