{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:37:43Z","timestamp":1783463863128,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dana Masyarakat Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada Yogyakarta Indonesia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Vascular Medicine"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Serum endothelin-1 is increasingly released in acute myocardial infarction, by necrotic cardiomyocytes. In non-ST-elevation acute myocardial infarction (Non-STEMI), increased serum endothelin-1 on-admission may have clinical significance during acute hospitalisation events. <jats:italic>Objective.<\/jats:italic> The purpose of this study is to investigate whether increased serum endothelin-1 level predict adverse cardiac events in patients hospitalized with Non-STEMI. <jats:italic>Methods<\/jats:italic>. The design of this research was a prospective cohort study. Consecutive subjects with Non-STEMI undergoing symptom onset \u226424\u2009hour were enrolled and observed during intensive hospitalization. Serum endothelin-1, troponin-I, and hs-C reactive protein were measured from peripheral blood taken on-admission. In-hospital adverse cardiac events were a composite of death, acute heart failure, cardiogenic shock, reinfarction, and resuscitated VT\/VF. <jats:italic>Results<\/jats:italic>. We enrolled 66 subjects. The incidence of in-hospital adverse cardiac events is 13.6% (10 out of 66 subjects). Serum endothelin-1 level was significantly higher in subjects with in-hospital adverse cardiac events. Subjects with endothelin-1 level &gt;2.59\u2009pg\/mL independently predicted adverse cardiac events in hospitalised Non-STEMI patients (adjusted odds ratio 44.43, 95% confidence interval: 1.44-1372.99, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><\/mml:math> value 0.03). The serum endothelin-1 level was correlated with serum troponin I level (correlation coefficient of 0.413, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><\/mml:math> value 0.012). <jats:italic>Conclusion<\/jats:italic>. Increased serum endothelin-1 on-admission correlated with increased troponin-I and independently predicted in-hospital adverse cardiac events in patients with Non-STEMI.<\/jats:p>","DOI":"10.1155\/2020\/9260812","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T23:32:49Z","timestamp":1596583969000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Serum Endothelin-1 Correlates with Myocardial Injury and Independently Predicts Adverse Cardiac Events in Non-ST-Elevation Acute Myocardial Infarction"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1033","authenticated-orcid":true,"given":"Anggoro Budi","family":"Hartopo","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indah","family":"Sukmasari","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Puspitawati","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budi Yuli","family":"Setianto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.095707"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.5.436"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1159\/000175848"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1159\/000006890"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80214-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.654"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.071"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2010.07.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.4.1573"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2434"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826e1058"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00505-6"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000021921.14653.28"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000428"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2011.278192"}],"container-title":["International Journal of Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2020\/9260812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2020\/9260812.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijvm\/2020\/9260812.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T23:32:52Z","timestamp":1596583972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijvm\/2020\/9260812\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":16,"alternative-id":["9260812","9260812"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9260812","relation":{},"ISSN":["2090-2824","2090-2832"],"issn-type":[{"value":"2090-2824","type":"print"},{"value":"2090-2832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]}}}