{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:29Z","timestamp":1753887869278,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Autoantibodies against apolipoprotein A\u20101 (anti\u2010ApoA\u20101 IgG) were demonstrated to be associated with cardiovascular outcomes in several inflammatory diseases. As balanced inflammation is critical for uncomplicated pregnancy, we aimed to investigate the prevalence of anti\u2010ApoA\u20101 IgG and anti\u2010c\u2010terminal ApoA\u20101 autoantibodies (Ac\u2010terAA1 IgG) in a cohort of pregnant women and their potential relationship with threatened abortion (TA). <jats:italic>Methods<\/jats:italic>. Between 2012 and 2014, 371 consecutive outpatient pregnant women were included in this study and followed until delivery. Anti\u2010ApoA\u20101 and anti\u2010Ac\u2010terAA1 IgG were measured by ELISA technique on serum samples collected between the 24<jats:sup>th<\/jats:sup> and 26<jats:sup>th<\/jats:sup> week of pregnancy. Associations with TA were tested using linear regression analysis and C\u2010statistics. <jats:italic>Results<\/jats:italic>. Median age was 34 with a prevalence of the Caucasian ethnicity (90.5%). TA occurred in 10 women (2.7%). C\u2010statistics indicated that anti\u2010ApoA\u20101 and anti\u2010Ac\u2010terAA1 IgG levels upon study inclusion were predictive of TA (0.73, 95% confidence interval [CI] 0.69\u20100.78, <jats:italic>p<\/jats:italic> &lt; 0.001 and 0.76, 95% CI 0.71\u20100.80, <jats:italic>p<\/jats:italic> = 0.01, respectively). At the prespecified anti\u2010ApoA\u20101 IgG cutoff, the negative predictive value (NPV) was 100%. For anti\u2010Ac\u2010terAA1 IgG, at the optimal cutoff, the NPV was 99%. Linear regression models indicated that risk associations were independent of age and the presence of autoimmune diseases for both autoantibodies (<jats:italic>p<\/jats:italic> &lt; 0.001). Anti\u2010Ac\u2010terAA1 IgG\u2010positive individuals were more frequently non\u2010Caucasians (<jats:italic>p<\/jats:italic> = 0.009). <jats:italic>Conclusion<\/jats:italic>. Anti\u2010ApoA\u20101 and anti\u2010Ac\u2010terAA1 IgG are independently associated with TA during pregnancy with an appealing NPV. The causal biological mechanisms underlying this association as well as the possible clinical relevance of these findings require further investigations.<\/jats:p>","DOI":"10.1155\/2020\/9309121","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T23:32:33Z","timestamp":1583623953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiapolipoprotein A\u20101 Autoantibody Positivity Is Associated with Threatened 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