{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:21:56Z","timestamp":1762093316388,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taihe Hospital","award":["2016JZ13","WJ2019F135"],"award-info":[{"award-number":["2016JZ13","WJ2019F135"]}]},{"name":"Foundations of Hubei Province Health and Family Planning Scientific Research Project","award":["2016JZ13","WJ2019F135"],"award-info":[{"award-number":["2016JZ13","WJ2019F135"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Epidemiological studies have demonstrated that interleukin\u201010 (IL\u201010) polymorphisms may be associated with the development of Behcet\u2019s disease (BD). However, the published results were inconsistent. Therefore, this meta\u2010analysis was conducted to derive a more precise relationship between IL\u201010 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL\u201010 \u20101082A&gt;G (rs1800896), \u2010819T&gt;C (rs1800871), and \u2010592A&gt;C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case\u2010control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between \u2010819T&gt;C polymorphisms and BD risk were observed in the total population (C vs. T: OR = 0.72, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI = 0.67\u20100.77,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 36.6\n                    <jats:italic>%<\/jats:italic>\n                    ; TC vs. TT: OR = 0.73, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI = 0.66\u20100.80,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 23.0\n                    <jats:italic>%<\/jats:italic>\n                    ; CC vs. TT: OR = 0.52, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI = 0.39\u20100.70,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 53.7\n                    <jats:italic>%<\/jats:italic>\n                    ; TC+CC vs. TT: OR = 0.67, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI = 0.61\u20100.71,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 22.1\n                    <jats:italic>%<\/jats:italic>\n                    ; and CC vs. TT+TC: OR = 0.66, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI = 0.53\u20100.82,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 57.8\n                    <jats:italic>%<\/jats:italic>\n                    ). Moreover, the IL\u201010 \u2010592 A&gt;C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta\u2010analysis suggested that IL\u201010 gene polymorphisms may play a salient role for BD development.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9382609","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T19:31:22Z","timestamp":1592595082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between Interleukin\u201010 Gene Polymorphisms and Behcet\u2019s Disease Susceptibility: Evidence from a Meta\u2010Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xue-Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-272X","authenticated-orcid":false,"given":"Yu-Ming","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-492X","authenticated-orcid":false,"given":"Jun-Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.08.013"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.208"},{"key":"e_1_2_11_4_2","first-page":"1078","article-title":"Criteria for diagnosis of Behcet\u2019s disease. 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