{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:15:02Z","timestamp":1769976902021,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Enteroviruses (EVs) can cause infections and outbreaks of mild to severe diseases, such as central nervous system (CNS) and systemic infections. The contribution of EVs to acute CNS\/systemic infections requiring hospitalization was assessed by analysing data extracted from virology laboratory database. <jats:italic>Methods<\/jats:italic>. Real\u2010life data obtained from two molecular virology laboratories located in Northern Italy were retrieved from databases and analysed retrospectively. The queries used to extract the data were (i) requests for EV\u2010RNA detection in clear cerebrospinal fluid (CSF) specimens collected from hospitalized patients with suspected acute CNS (including aseptic meningitis, encephalitis, and acute flaccid myelitis\/paralysis) or systemic infections (sepsis\u2010like illness or fever (\u2265 38\u00b0C) of unknown origin), (ii) CSF samples collected from January 1st, 2015, to December 31st, 2017. <jats:italic>Results<\/jats:italic>. 582 requests of EV\u2010RNA detection in CSF samples collected from as many patients of any age were recorded. EV\u2010RNA was detected in 4.5% of the CSF samples; 92.3% of EV\u2010positive cases were patients &lt; 15\u2009years, 58.3% of whom were &lt; 3 months. EVs circulated all\u2010year\u2010round, and the highest EV\u2010positive rates were observed from May to August. The risk of EV infection and the relative illness ratio value among children &lt; 1 \u2212 year \u2212 old were significantly higher than those observed for older patients. <jats:italic>Conclusions<\/jats:italic>. EV surveillance should be carried out for all pediatric patients &lt; 15\u2009years and especially children less than 1 year of age with clinically suspected CNS infection\/systemic infections. The implementation of a laboratory\u2010based surveillance established for analysing the virological data provided by laboratories that routinely perform EV molecular testing may enable us to determine the impact of EVs that can cause infections requiring hospitalization.<\/jats:p>","DOI":"10.1155\/2020\/9393264","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T23:34:08Z","timestamp":1593732848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contribution of Enteroviruses to Acute Central Nervous System or Systemic Infections in Northern Italy (2015\u20102017): Is It Time to Establish a National Laboratory\u2010Based Surveillance System?"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-2579","authenticated-orcid":false,"given":"Antonio","family":"Piralla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-6032","authenticated-orcid":false,"given":"Laura","family":"Pellegrinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-0940","authenticated-orcid":false,"given":"Federica","family":"Giardina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-4156","authenticated-orcid":false,"given":"Cristina","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-3183","authenticated-orcid":false,"given":"Sandro","family":"Binda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-3455","authenticated-orcid":false,"given":"Elena","family":"Pariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3358-8969","authenticated-orcid":false,"given":"Fausto","family":"Baldanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.dmih2-0006-2015"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.05.005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2300-5"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000937"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21031"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","unstructured":"SullivanK. 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