{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:23:29Z","timestamp":1762093409392,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":301,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Although\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    infections in blood donors have been reported, the impact of parasitaemia on cytokine levels in stored whole blood has not been explored. This study evaluated the effect of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    parasitaemia on circulating cytokines and their relationship with haematological parameters in banked blood. In this case\u2010control study, two groups of donor whole blood were recruited:\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    \u2010infected donors (parasitaemia: 515\u20131877 parasites\/\n                    <jats:italic>\u03bc<\/jats:italic>\n                    L) and noninfected blood donors (control). At day 0 (baseline), 7, 14, 21, and 35 of banking circulating cytokine levels of tumor necrosis factor alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), interleukin\u2010 (IL\u2010) 12, IL\u201010, and IL\u20106 levels and haematological parameters were determined. Kruskal\u2010Wallis test determined differences in weekly cytokine levels while Dunn\u2019s post hoc test determined exact significant points. At baseline, the mean TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (33.81\u2009pg\/mL vs. 22.70\u2009pg\/mL), IL\u201012 (28.39\u2009pg\/mL vs. 16.15\u2009pg\/mL), IL\u201010 (51.04\u2009pg\/mL vs. 18.95\u2009pg\/mL), and IL\u20106 (71.03\u2009pg\/mL vs. 30.89\u2009pg\/mL) levels were significantly higher in infected donor whole blood. Significant rate of increase was observed in TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u201012 levels, and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/IL\u201010 ratios in infected blood, while decreased levels were observed in IL\u201010. IL\u20106 peaked at day 21 and fell below baseline level at day 35. Significant changes in TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u201012, IL\u201010, IL\u20106 levels, and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/IL\u201010 ratios in infected donor blood were observed 7 days after storage. Unlike in noninfected stored whole blood, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, IL\u201012, and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/IL\u201010 ratio levels in infected stored whole blood related inversely to haematological parameters (white cells, red cells, platelets, and haemoglobin levels) during storage. However, in both groups, significant direct relationship was observed in IL\u201010 and haematological parameters. In conclusion, banking of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    \u2010infected donor whole blood may lead to infusion of large quantities of inflammatory cytokines with potential adverse immunological response in recipients.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9394585","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T19:20:08Z","timestamp":1603912808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elevated IL\u201012, TNF\u2010\n                    <i>\u03b1<\/i>\n                    , and TNF\u2010\n                    <i>\u03b1<\/i>\n                    \/IL\u201010 Ratios in Stored\n                    <i>Plasmodium falciparum<\/i>\n                    \u2010Infected Whole Blood: Implications for Safe Haemotransfusion"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-167X","authenticated-orcid":false,"given":"Enoch","family":"Aninagyei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9686-8300","authenticated-orcid":false,"given":"Patrick","family":"Adu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-3256","authenticated-orcid":false,"given":"Alexander","family":"Egyir-Yawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-2618","authenticated-orcid":false,"given":"Desmond Omane","family":"Acheampong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_1_2","DOI":"10.1016\/s0031-3025(16)34566-4"},{"doi-asserted-by":"publisher","key":"e_1_2_11_2_2","DOI":"10.1093\/cid\/cit130"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_2","DOI":"10.1309\/LMZ18YTESFA8PLFR"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_2","DOI":"10.4314\/njpar.v25i1.37712"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_2","DOI":"10.4103\/0973-6247.98937"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_2","DOI":"10.1590\/s1678-9946201759043"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_2","DOI":"10.1186\/s12936-018-2476-1"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_2","DOI":"10.1111\/j.1423-0410.2005.00661.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_2","DOI":"10.1186\/s12936-018-2181-0"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_2","DOI":"10.1111\/j.1537-2995.2010.02872.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_2","DOI":"10.1046\/j.1537-2995.1991.31992094662.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_2","DOI":"10.1186\/s12878-018-0128-x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_2","DOI":"10.1111\/j.1423-0410.2006.00778.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_2","DOI":"10.1006\/clim.2001.5057"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_2","DOI":"10.1128\/cdli.9.2.348-351.2002"},{"key":"e_1_2_11_16_2","article-title":"Guidelines on assessing donor suitability for blood donation","author":"WHO","year":"2012","journal-title":"World Health Organization"},{"doi-asserted-by":"publisher","key":"e_1_2_11_17_2","DOI":"10.1186\/s12936-019-2850-7"},{"volume-title":"Basic Malaria Microscopy: Part I Learner\u2019s Guide","year":"1991","author":"WHO","key":"e_1_2_11_18_2"},{"doi-asserted-by":"publisher","key":"e_1_2_11_19_2","DOI":"10.3126\/jpn.v7i1.16949"},{"doi-asserted-by":"publisher","key":"e_1_2_11_20_2","DOI":"10.1128\/IAI.72.10.5630-5637.2004"},{"doi-asserted-by":"publisher","key":"e_1_2_11_21_2","DOI":"10.25100\/cm.v41i4.723"},{"doi-asserted-by":"publisher","key":"e_1_2_11_22_2","DOI":"10.1086\/315016"},{"doi-asserted-by":"publisher","key":"e_1_2_11_23_2","DOI":"10.4103\/0973-6247.162708"},{"doi-asserted-by":"publisher","key":"e_1_2_11_24_2","DOI":"10.1097\/00000542-200211000-00011"},{"doi-asserted-by":"publisher","key":"e_1_2_11_25_2","DOI":"10.1097\/01.CCM.0000104112.34142.79"},{"doi-asserted-by":"publisher","key":"e_1_2_11_26_2","DOI":"10.1007\/s00134-010-1867-8"},{"doi-asserted-by":"publisher","key":"e_1_2_11_27_2","DOI":"10.1186\/1742-2094-7-16"},{"doi-asserted-by":"publisher","key":"e_1_2_11_28_2","DOI":"10.1073\/pnas.72.9.3666"},{"doi-asserted-by":"publisher","key":"e_1_2_11_29_2","DOI":"10.1016\/S1471-4906(02)00013-3"},{"doi-asserted-by":"publisher","key":"e_1_2_11_30_2","DOI":"10.2741\/1341"},{"doi-asserted-by":"publisher","key":"e_1_2_11_31_2","DOI":"10.1038\/35100529"},{"doi-asserted-by":"publisher","key":"e_1_2_11_32_2","DOI":"10.1084\/jem.178.3.1041"},{"doi-asserted-by":"publisher","key":"e_1_2_11_33_2","DOI":"10.1515\/ii-2017-0103"},{"doi-asserted-by":"publisher","key":"e_1_2_11_34_2","DOI":"10.1016\/j.ajpath.2013.09.017"},{"doi-asserted-by":"publisher","key":"e_1_2_11_35_2","DOI":"10.1038\/nri956"},{"doi-asserted-by":"publisher","key":"e_1_2_11_36_2","DOI":"10.1371\/journal.ppat.1003208"},{"doi-asserted-by":"publisher","key":"e_1_2_11_37_2","DOI":"10.1111\/j.1365-2141.1988.tb02440.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_38_2","DOI":"10.1086\/314548"},{"doi-asserted-by":"publisher","key":"e_1_2_11_39_2","DOI":"10.1093\/bjaceaccp\/mkl053"},{"key":"e_1_2_11_40_2","first-page":"791","volume-title":"Oxford Textbook of Medicine","author":"Perrotta P. L.","year":"2003"},{"key":"e_1_2_11_41_2","first-page":"1613","volume-title":"Anaesthesia","author":"Miller R. D.","year":"2000"},{"doi-asserted-by":"publisher","key":"e_1_2_11_42_2","DOI":"10.1111\/j.1537-2995.2011.03103.x"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9394585.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9394585.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/9394585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:18:57Z","timestamp":1762093137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/9394585"}},"subtitle":[],"editor":[{"given":"Zhipeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/9394585"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9394585","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9394585"}}