{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:57:59Z","timestamp":1791849479360,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":160,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007861","name":"University of Gondar","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Treatment of malaria has been compromised by the emergence of drug\u2010resistant parasites. Consequently, novel agents are urgently needed from different sources including from medicinal plants. Thus, the current study aimed at evaluating the antimalarial activity of crude extract and solvent fractions of the leaves of\n                    <jats:italic>Bersama abyssinica (B. abyssinica)<\/jats:italic>\n                    against\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    infection in\n                    <jats:italic>Swiss<\/jats:italic>\n                    Albino mice.\n                    <jats:italic>Method<\/jats:italic>\n                    . A 4\u2010day suppressive test was employed to evaluate the antimalarial effect of crude extract and solvent fractions against early infection. The curative and prophylactic effects of crude extract and fraction with the highest chemosuppression were further tested by Rane\u2019s test and residual infection procedure. Parasitemia, survival time, packed cell volume (PCV), body weight, and rectal temperature of mice were used as evaluation parameters. Windows SPSS version 20 was used to analyze the data and analysis of variance (ANOVA) followed by Tukey\u2019s post hoc test was used to compare data between groups.\n                    <jats:italic>Results<\/jats:italic>\n                    . The crude extract and aqueous fraction significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05 to 0.001) suppressed parasitemia followed by protection of PCV reduction resulting in prolonging the survival time but failed to protect body weight and rectal temperature reduction in all tested models. The ethyl acetate and chloroform fractions also showed significant chemosuppression and PCV protection in the 4\u2010day suppressive test. The crude extract exhibited a chemosuppression of 49.51%, 57.94%, and 44.11% while the aqueous fraction showed suppression of 47.69%, 51.62%, and 37.07% in 4\u2010day suppressive, curative, and prophylactic tests, respectively, at 400\u2009mg\/kg.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The crude extract and fractions showed fairly moderate antimalarial activity, and the finding supports the traditional claims and previous\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies. Thus, this may call for further studies to isolate chemical entities for additional safety and efficacy tests.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9467359","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T19:31:58Z","timestamp":1591731118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of\n                    <i>Bersama abyssinica<\/i>\n                    Fresen. (Melianthaceae) against\n                    <i>Plasmodium berghei<\/i>\n                    Infection in\n                    <i>Swiss<\/i>\n                    Albino Mice"],"prefix":"10.1155","volume":"2020","author":[{"given":"Agumas Alemu","family":"Alehegn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-7119","authenticated-orcid":false,"given":"Jibril Seid","family":"Yesuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-0384","authenticated-orcid":false,"given":"Eshetie Melese","family":"Birru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.01.002"},{"key":"e_1_2_12_2_2","volume-title":"World Malaria Report 2019","author":"WHO","year":"2019"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0259"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0487-3"},{"key":"e_1_2_12_5_2","volume-title":"National Strategic Plan for Malaria Prevention, Control and Elimination in Ethiopia, 2011\u20132015","author":"FMOH","year":"2015"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.9734\/bjast\/2011\/273"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-016-0077-0"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0001-37652009000400011"},{"key":"e_1_2_12_9_2","volume-title":"Medicines for malaria venture (MMV) 2005\u20132010. 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