{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:22:57Z","timestamp":1762093377890,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":224,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Diabetes Association","award":["2015"],"award-info":[{"award-number":["2015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Forkhead box O (FOXO) transcription factors have been implicated in the development and differentiation of the immune cells. FOXO3 plays a crucial role in physiologic and pathologic immune response. FOXO3, cooperatively with FOXO1, control the development and function of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    ). Since the lack of T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010mediated control has fundamental impact on type 1 diabetes mellitus (T1DM) development, we investigated\n                    <jats:italic>FOXO3<\/jats:italic>\n                    expression in patients with T1DM.\n                    <jats:italic>FOXO3<\/jats:italic>\n                    expression was estimated in peripheral blood mononuclear cells (PBMCs) from newly diagnosed T1DM pediatric patients (\n                    <jats:italic>n<\/jats:italic>\n                    = 28) and age\u2010matched healthy donors (\n                    <jats:italic>n<\/jats:italic>\n                    = 27) by reahavel\u2010time PCR and TaqMan gene expression assays. Expression analysis revealed significant upregulation of\n                    <jats:italic>FOXO3<\/jats:italic>\n                    in T1DM (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0005). Stratification of the T1DM group according to the presence of initial diabetic ketoacidosis (DKA) did not indicate differences in\n                    <jats:italic>FOXO3<\/jats:italic>\n                    expression in patients with DKA compared to a mild T1DM onset (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05). In conclusion, overexpression of\n                    <jats:italic>FOXO3<\/jats:italic>\n                    is correlated with the ongoing islet autoimmune destruction and might suggest a potential role for this gene in the pathogenesis of type 1 diabetes mellitus.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9484015","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:43:02Z","timestamp":1597261382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Upregulation of\n                    <i>FOXO3<\/i>\n                    in New\u2010Onset Type 1 Diabetes Mellitus"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-4054","authenticated-orcid":false,"given":"Magdalena","family":"Zurawek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Czainska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Rozwadowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1623"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80595-4"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2003.172.re5"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1729"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.12.002"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002533"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.109991"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.010"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08933"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1331"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01621"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.05.044"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0979"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.460"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9484015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/9484015.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/9484015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:18:20Z","timestamp":1762093100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/9484015"}},"subtitle":[],"editor":[{"given":"Cinzia","family":"Ciccacci","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/9484015"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9484015","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9484015"}}