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The results showed that methionine supplementation enhanced liver GSH\u2010Px activity and upregulated Gpx1 expression in the liver and SOD1 and Gpx4 expressions in the jejunum. Nrf2\/Keap1 is involved in oxidative stress, and the western blotting data exhibited that dietary methionine markedly increased Keap1 abundance, while failed to influence the Nrf2 signal. Metabolomics investigation showed that methionine administration increased 2\u2010hydroxypyridine, salicin, and asparagine and reduced D\u2010Talose, maltose, aminoisobutyric acid, and inosine 5\u2019\u2010monophosphate in the liver, which are widely reported to involve in oxidative stress, lipid metabolism, and nucleotides generation. 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