{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:18Z","timestamp":1747190358832,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure. <jats:italic>Background<\/jats:italic>. RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation. <jats:italic>Methods<\/jats:italic>. We enrolled 82 consecutive patients (mean age, 49\u2009\u00b1\u200918 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. The relationship between RV volume and peak oxygen uptake (VO<jats:sub>2<\/jats:sub>) was evaluated. <jats:italic>Results<\/jats:italic>. The mean RV end-diastolic volume index was 108\u2009\u00b1\u200927\u2009ml\/m<jats:sup>2<\/jats:sup> (range, 46 to 180\u2009ml\/m<jats:sup>2<\/jats:sup>). The mean peak VO<jats:sub>2<\/jats:sub> was 24\u2009\u00b1\u20097\u2009ml\/min\/kg (range, 14 to 48\u2009ml\/min\/kg), and the mean predicted peak VO<jats:sub>2<\/jats:sub> was 90\u2009\u00b1\u200923%. There were significant negative relationships of RV end-diastolic volume index with peak VO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.28, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) and predicted peak VO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.29, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). The cutoff value of RV end-diastolic volume index &lt;80% of predicted peak VO<jats:sub>2<\/jats:sub> was 120\u2009ml\/m<jats:sup>2<\/jats:sup>, with the sensitivity of 49% and the specificity of 89%. <jats:italic>Conclusions<\/jats:italic>. There was a relationship between RV dilatation and exercise capacity in adult patients with ASD. RV end-diastolic volume index \u2265120\u2009ml\/m<jats:sup>2<\/jats:sup> was related to the reduction in peak VO<jats:sub>2<\/jats:sub>. This criterion of RV dilatation may be valuable for the indication of transcatheter ASD closure.<\/jats:p>","DOI":"10.1155\/2020\/9509105","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:32:32Z","timestamp":1588116752000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect"],"prefix":"10.1155","volume":"2020","author":[{"given":"Rie","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-1597","authenticated-orcid":true,"given":"Yoichi","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and 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University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Division of Medical Support, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University 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