{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:57:38Z","timestamp":1740149858847,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["APP-2\/2016"],"award-info":[{"award-number":["APP-2\/2016"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2020,7,2]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The progression of <jats:italic>Helicobacter pylori<\/jats:italic>-associated gastritis towards atrophic gastritis is modulated by host-related and environmental factors. Studies that explore the possible involvement of host-related versus environmental factors in the development of gastritis phenotype induced by <jats:italic>H. pylori<\/jats:italic> are highly needed. <jats:italic>Aims<\/jats:italic>. Our study was aimed at investigating the phenotype of <jats:italic>H. pylori<\/jats:italic>-associated gastritis in two cohorts of monozygotic and dizygotic twins, using the OLGA\/OLGIM gastritis staging system. <jats:italic>Methods<\/jats:italic>. Two cohorts of monozygotic (14 pairs) and dizygotic (15 pairs) dyspeptic twins prospectively underwent endoscopy with biopsy sampling based on Sydney protocol. <jats:italic>H. pylori<\/jats:italic> status and OLGA\/OLGIM stages were assessed and compared. <jats:italic>Results<\/jats:italic>. The mean age of monozygotic and dizygotic twins was 40.4 and 38.6 years, respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.623<\/mml:mn><\/mml:math>). The overall prevalence of <jats:italic>H. pylori<\/jats:italic> infection was 51.7%. Among the 14 monozygotic twin pairs, five pairs were <jats:italic>H. pylori<\/jats:italic>-positive, four were <jats:italic>H. pylori<\/jats:italic>-negative, and five were <jats:italic>H. pylori<\/jats:italic>-discordant. Among the 15 dizygotic twin pairs, five pairs were <jats:italic>H. pylori<\/jats:italic>-positive, five were <jats:italic>H. pylori<\/jats:italic>-negative, and five were <jats:italic>H. pylori<\/jats:italic>-discordant. Concordance for antrum atrophy in monozygotic twins was 78.6% (11\/14 pairs) and in dizygotic twins 73.3% (11\/15 pairs) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.742<\/mml:mn><\/mml:math>). Concordance for corpus atrophy in monozygotic versus dizygotic twins was 92.9% (13\/14 pairs) and 86.7% (13\/15 pairs), respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.584<\/mml:mn><\/mml:math>). Concordance for antrum intestinal metaplasia (IM) in monozygotic twins was 85.7% (12\/14 pairs) and in dizygotic 73.3% (11\/15 pairs) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.411<\/mml:mn><\/mml:math>). Concordance for corpus IM in monozygotic twins was 85.7% (12\/14 pairs) and in dizygotic 86.7% (13\/15 pairs) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.941<\/mml:mn><\/mml:math>). Among monozygotic and dizygotic subjects, the stage of gastritis was concordant in both <jats:italic>H. pylori<\/jats:italic>-positive and <jats:italic>H. pylori<\/jats:italic>-negative subjects. <jats:italic>Conclusions<\/jats:italic>. In conclusion, histological gastric mucosa alterations in monozygotic and dizygotic twins showed high rates of concordance. Furthermore, OLGA\/OLGIM gastritis stages were not modulated by the zygosity of the twins.<\/jats:p>","DOI":"10.1155\/2020\/9510717","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T23:34:10Z","timestamp":1593732850000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins"],"prefix":"10.1155","volume":"2020","author":[{"given":"Mindaugas","family":"Urba","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgita","family":"Skieceviciene","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dainius","family":"Janciauskas","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Lithuanian University of Health Sciences, Kaunas LT 50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laimas","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limas","family":"Kupcinskas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua 35121, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua 35121, Italy"},{"name":"Veneto Cancer Registry, Regional Authority, Padova 35100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-7416","authenticated-orcid":true,"given":"Juozas","family":"Kupcinskas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, 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