{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:16:53Z","timestamp":1753885013549,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The purpose of this study was to evaluate various objective, quantitative, time\u2010resolved fluoroscopic imaging parameters for use in the peri\u2010interventional evaluation of stenotic peripheral arterial disease lesions. <jats:italic>Material and Methods<\/jats:italic>. Ten patients (median age, 64; age range, 52 to 79; 8 males, 2 females) with high\u2010grade stenoses of either the superficial femoral or popliteal arteries who underwent endovascular treatment were included. During each intervention, two series of intraprocedural fluoroscopic images were collected, one preintervention and one postintervention. For each imaging series, four regions of interest (ROIs) were defined within the vessel lumen, with two ROIs being proximal (ROIs 1 and 2) and two being distal (ROIs 3 and 4) to the stenosis. The time\u2010density curve (TDC) at each ROI was measured, and the resulting area under the curve (AUC), full width at half maximum (FWHM), and time\u2010to\u2010peak (TTP) were then calculated. <jats:italic>Results<\/jats:italic>. The analysis of the TDC\u2010derived parameters demonstrated significant differences between pre\u2010 and postinterventional flow rates in the ROI placed most distal to the stenosis, ROI 4. The AUC at ROI 4 (reported as a relative percentage of the AUC measured at ROI 1 proximal to the lesion) demonstrated a significant increase in the total flow (mean 67.84% vs. 128.68%, <jats:italic>p<\/jats:italic> = 0.003). A significant reduction in FWHM at ROI 4 (mean 2.93\u2009s vs. 1.87\u2009s, <jats:italic>p<\/jats:italic> = 0.015) was observed. A significant reduction in TTP at ROI 4 (2.43\u2009s to 1.45\u2009s, <jats:italic>p<\/jats:italic> = 0.009) was also observed. A positive change in at least 1 of the 3 calculated parameters was seen in all patients after a successful intervention, with 7 of 10 patients showing improvement in all 3 parameters, 2 of 10 showing improvement in 2 parameters, and 1 patient showing improvement in 1 parameter. <jats:italic>Conclusion<\/jats:italic>. AUC, FWHM, and TTP are objective, reproducible, quantifiable tools for the peri\u2010interventional fluoroscopic evaluation of vessel stenoses. When compared to the standard subjective interpretation of fluoroscopic imagery, AUC, FWHM, and TTP offer interventionalists the advantage of having an objective, complementary method of evaluating the success of a procedure, potentially allowing for more precisely targeted and quantitatively determined treatment goals and improved patient outcomes. This retrospective study was approved by the local ethics committee under the Number 372\/2018BO2. The trial was registered at the German clinical trials register under the number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.drks.de\/drks_web\/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00017813\">DRKS00017813<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2020\/9526790","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T23:31:00Z","timestamp":1579217460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative Evaluation of Peripheral Arterial Blood Flow Using Peri\u2010Interventional Fluoroscopic Parameters: An In Vivo Study Evaluating Feasibility and Clinical Utility"],"prefix":"10.1155","volume":"2020","author":[{"given":"Patrick","family":"Ghibes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Hefferman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Nikolaou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Syha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Artzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-3128","authenticated-orcid":false,"given":"Ulrich","family":"Grosse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-187X","authenticated-orcid":false,"given":"Gerd","family":"Gr\u00f6zinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.23736\/s0021-9509.17.10245-4"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rvi.0000240426.53079.46"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-014-0876-3"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.179"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-013-0741-9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1670-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1903-2"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/873614"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a3049"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2478\/romneu-2013-0014"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a3838"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.03.424"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161806"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2015.02.018"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.02.011"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.15274\/INR-2014-10086"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019917721867"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000468157"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185330"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112007005836"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1385840"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6180138"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602817698634"},{"key":"e_1_2_9_24_2","first-page":"240","article-title":"Intravascular ultrasound assessment and correlation with angiographic findings demonstrating femoropopliteal arterial dissections post atherectomy: results from the iDissection study","volume":"30","author":"Shammas N. 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