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Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was designed at investigating the protective potential and mechanism(s) of CVE and IGE in TZM-induced cardiotoxicity utilizing cardiac enzyme and oxidative stress markers and histopathological endpoints. 400\u2009mg\/kg\/day CVE and IGE dissolved in 5% DMSO in sterile water were investigated in Wistar rats injected with 2.25\u2009mg\/kg\/day\/i.p. route of TZM for 7 days, using serum cTnI and LDH, complete lipid profile, cardiac tissue oxidative stress markers assays, and histopathological examination of TZM-intoxicated heart tissue. Results showed that 400\u2009mg\/kg\/day CVE and IGE profoundly attenuated increases in the serum cTnI and LDH levels but caused no significant alterations in the serum lipids and weight gain pattern in the treated rats. CVE and IGE profoundly attenuated alterations in the cardiac tissue oxidative stress markers\u2019 activities while improving TZM-associated cardiac histological lesions. These results suggest that CVE and IGE could be mediating its cardioprotection via antioxidant, free radical scavenging, and antithrombotic mechanisms, thus, highlighting the therapeutic potentials of CVE and IGE in the management of TZM-mediated cardiotoxicity.<\/jats:p>","DOI":"10.1155\/2020\/9535426","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T21:20:06Z","timestamp":1602796806000},"page":"1-15","source":"Crossref","is-referenced-by-count":6,"title":["African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats"],"prefix":"10.1155","volume":"2020","author":[{"given":"Olufunke","family":"Olorundare","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-6282","authenticated-orcid":true,"given":"Adejuwon","family":"Adeneye","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinyele","family":"Akinsola","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday","family":"Soyemi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Mgbehoma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"Okoye","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Medicine, Faculty of Dentistry, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Ntambi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-077X","authenticated-orcid":true,"given":"Hasan","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Wisconsin, Madison, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tby003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2619"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614529603"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042513-015127"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1435746"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0741"},{"issue":"1","key":"7","first-page":"1005","article-title":"Implications of autophagy and oxidative stress in trastuzumab-mediated cardiac toxicities","volume":"2","author":"N. 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