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This study investigated the mechanism of miR\u2010148b\/SIRT7 on how it affects the malignant biological behavior of melanoma. It was established that the expression of miR\u2010148b was downregulated in melanoma while that of SIRT7 was upregulated but negatively regulated by miR\u2010148b through binding to the 3\u2009<jats:sup>\u2032<\/jats:sup>UTR of SIRT7. Ectopic expression of miR\u2010148b reduced the proliferation, migration, and invasion of melanoma cells, but SIRT7 reversed these functions of miR\u2010148b. Moreover, tumor growth and metastasis experiments showed that miR\u2010148b could significantly suppress proliferation and metastasis of melanoma <jats:italic>in vivo<\/jats:italic>. Overall, miR\u2010148b inhibits the malignant biological behavior of melanoma by reducing the expression level of SIRT7. 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