{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:41:12Z","timestamp":1794084072090,"version":"4.8.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2020,1,29]]},"abstract":"<jats:p>Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarc\u00f3n-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women. The mean age at presentation was 39.3 years (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>SD<\/mml:mtext><mml:mo>\u00b1<\/mml:mo><mml:mn>11.6<\/mml:mn><\/mml:math>). The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%). The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5). The Kahn criteria and Alarc\u00f3n-Segovia criteria had the maximum specificity; the Alarc\u00f3n-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9). The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively.<\/jats:p>","DOI":"10.1155\/2020\/9692030","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T18:33:34Z","timestamp":1580322814000},"page":"1-6","source":"Crossref","is-referenced-by-count":59,"title":["Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-0294","authenticated-orcid":true,"given":"Kevin John","family":"John","sequence":"first","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"George","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Rajadurai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thambu David","family":"Sudarsanam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90064-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(80)90013-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143792"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121272"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.010"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(86)90047-8"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1494-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.007"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.07.010"},{"key":"10","first-page":"23","volume-title":"Diagnostic 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