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We recruited 329 cognitively normal right-handed Han Chinese subjects who completed <jats:italic>ApoE<\/jats:italic> gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with <jats:italic>ApoE \u025b3\/4<\/jats:italic> and <jats:italic>4\/4<\/jats:italic> [0.6074 (0.6541) ng\/mL] than in subjects without <jats:italic>ApoE \u025b4<\/jats:italic> [0.4368 (0.3392) ng\/mL and 0.5287 (0.3656) ng\/mL], and urinary AD7c-NTP levels positively correlated with <jats:italic>ApoE<\/jats:italic> genotype grade (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.165<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>). There were significant differences in urinary AD7c-NTP levels between subjects with and without a history of coronary heart disease or diabetes. Urinary AD7c-NTP levels were not related to years of education, nature of work, family history of dementia, a history of hypertension, stroke, anemia, or thyroid dysfunction. Urinary AD7c-NTP levels were positively correlated with <jats:italic>ApoE<\/jats:italic> grade in the cognitively normal population. The relationship between risk factors of cognitive decline and urinary AD7c-NTP levels provides a new way for us to understand AD and urinary AD7c-NTP.<\/jats:p>","DOI":"10.1155\/2020\/9742138","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T23:30:57Z","timestamp":1591486257000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-8538","authenticated-orcid":true,"given":"Yuxia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"},{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, 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