{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T19:06:26Z","timestamp":1771700786827,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Osteoporosis is a disease characterized by decreased bone density and destruction of bone microarchitecture. Indicators for altered bone homeostasis are changes in the serum level of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). The purpose of the current study was to evaluate the effect of a 12\u2010week exercise program on enzyme activity of serum MMP\u20109 and TIMP\u20101 in postmenopausal osteoporotic patients. <jats:italic>Materials and methods<\/jats:italic>. Participants were randomized in two groups: exercise (EG) (<jats:italic>N<\/jats:italic>\u2009=\u200937) and control (CG) (<jats:italic>N<\/jats:italic>\u2009=\u200931). The exercise group completed a 12\u2010week supervised exercise program, while the control group did not take part in any physical activity. Enzyme activities of serum MMP\u20109 and TIMP\u20101 were detected by gelatin zymography and ELISA in both groups, respectively. <jats:italic>Results<\/jats:italic>. Significant differences between pretreatment and posttreatment enzyme activities of serum MMP\u20109 (<jats:italic>p<\/jats:italic> = 0.009), TIMP\u20101 (<jats:italic>p<\/jats:italic> \u2264 0.001), and MMP\u20109\/TIMP\u20101 ratio (<jats:italic>p<\/jats:italic> \u2264 0.001) were detected in the exercise group. Exercises decreased the activity of serum MMP\u20109 and increased the activity of TIMP\u20101, while the enzyme activities of MMP\u20109 (0.583) and TIMP\u20101 (0.210) have not been significantly changed in CG. Patients from the exercise group had better treatment. <jats:italic>Conclusion<\/jats:italic>. Our results suggest that a 12\u2010week exercise program has an influence on enzyme activity of serum MMP\u20109, revealing a possible role of MMPs in initiating training\u2010specific adaptation. Although measurements of circulating MMP\u20109 and TIMP\u20101 allowed us to detect effects of exercise, as of today, they have no real role in the diagnosis of osteoporosis and\/or follow\u2010up of osteoporotic patient\u2019s response to treatment. MMP\u20109 might be used as an important prognostic marker for the evaluation of patient\u2019s response to exercise. Larger\u2010randomized controlled studies need to be performed to expand this area of knowledge. This trial is registered with trial registration number: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03816449\">NCT03816449<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2020\/9758289","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T23:32:22Z","timestamp":1580427142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of 12\u2010Week Exercise Program on Enzyme Activity of Serum Matrix Metalloproteinase\u20109 and Tissue Inhibitor of Metalloproteinase\u20101 in Female Patients with Postmenopausal Osteoporosis: A Randomized Control 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