{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:58Z","timestamp":1787017678694,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Prunella vulgaris<\/jats:italic>\n                    (PV) has a long history of application in traditional Chinese and Western medicine as a remedy for the treatment of subacute thyroiditis (SAT). This study applied network pharmacology to elucidate the mechanism of the effects of PV against SAT. Components of the potential therapeutic targets of PV and SAT\u2010related targets were retrieved from databases. To construct a protein\u2010protein interaction (PPI) network, the intersection of SAT\u2010related targets and PV\u2010related targets was input into the STRING platform. Gene ontology (GO) analysis and KEGG pathway enrichment analysis were carried out using the DAVID database. Networks were constructed by Cytoscape for visualization. The results showed that a total of 11 compounds were identified according to the pharmacokinetic parameters of ADME. A total of 126 PV\u2010related targets and 2207 SAT\u2010related targets were collected, and 83 overlapping targets were subsequently obtained. The results of the KEGG pathway and compound\u2010target\u2010pathway (C\u2010T\u2010P) network analysis suggested that the anti\u2010SAT effect of PV mainly occurs through quercetin, luteolin, kaempferol, and beta\u2010sitosterol and is most closely associated with their regulation of inflammation and apoptosis by targeting the PIK3CG, MAPK1, MAPK14, TNF, and PTGS2 proteins and the PI3K\u2010Akt and TNF signaling pathways. The study demonstrated that quercetin, luteolin, kaempferol, and beta\u2010sitosterol in PV may play a major role in the treatment of SAT, which was associated with the regulation of inflammation and apoptosis, by targeting the PI3K\u2010Akt and TNF signaling pathways.\n                  <\/jats:p>","DOI":"10.1155\/2020\/9810709","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T22:35:09Z","timestamp":1605220509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of the Molecular Mechanisms of the Effects of\n                    <i>Prunella vulgaris<\/i>\n                    against Subacute Thyroiditis Based on Network Pharmacology"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xin","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9376-4066","authenticated-orcid":false,"given":"Xia","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00047"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf03347442"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0740"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021799"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121489"},{"key":"e_1_2_10_6_2","first-page":"2082","article-title":"Expert consensus statement on treatment of goiter\/nodular thyroid disease with xiakucao oral liquid in clinical practice","volume":"51","author":"Wei J. 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