{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:55:30Z","timestamp":1783727730886,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AIRC Foundation","award":["2013\/14129"],"award-info":[{"award-number":["2013\/14129"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic> To evaluate signal intensity (SI) differences between 3.0\u2009T and 1.5\u2009T on T2\u2010weighted (T2w), diffusion\u2010weighted imaging (DWI), and apparent diffusion coefficient (ADC) in rectal cancer pre\u2010, during, and postneoadjuvant chemoradiotherapy (CRT). <jats:italic>Materials and Methods<\/jats:italic>. 22 patients with locally advanced rectal cancer were prospectively enrolled. All patients underwent T2w, DWI, and ADC pre\u2010, during, and post\u2010CRT on both 3.0\u2009T MRI and 1.5\u2009T MRI. A radiologist drew regions of interest (ROIs) of the tumor and obturator internus muscle on the selected slice to evaluate SI and relative SI (rSI). Additionally, a subanalysis evaluating the SI before and after\u2010CRT (<jats:italic>\u2206<\/jats:italic>SI pre\u2010post) in complete responder patients (CR) and nonresponder patients (NR) on T2w, DWI, and ADC was performed. <jats:italic>Results.<\/jats:italic> Significant differences were observed for T2w and DWI on 3.0\u2009T MRI compared to 1.5\u2009T MRI pre\u2010, during, and post\u2010CRT (all <jats:italic>P<\/jats:italic> &lt; 0.001), whereas no significant differences were reported for ADC among all controls (all <jats:italic>P<\/jats:italic> &gt; 0.05). rSI showed no significant differences in all the examinations for all sequences (all <jats:italic>P<\/jats:italic> &gt; 0.05). <jats:italic>\u2206<\/jats:italic>SI showed significant differences between 3.0\u2009T and 1.5\u2009T MRI for DWI\u2010<jats:italic>\u2206<\/jats:italic>SI in CR and NR (188.39 \u00b1 166.90 vs. 30.45 \u00b1 21.73 and 169.70 \u00b1 121.87 vs. 22.00 \u00b1 31.29, respectively, all <jats:italic>P<\/jats:italic> 0.02) and ADC\u2010<jats:italic>\u2206<\/jats:italic>SI for CR (\u22120.58 \u00b1 0.27 vs. \u22120.21 \u00b1 0.24<jats:italic>P<\/jats:italic> value 0.02), while no significant differences were observed for ADC\u2010<jats:italic>\u2206<\/jats:italic>SI in NR and both CR and NR for T2w\u2010<jats:italic>\u2206<\/jats:italic>SI. <jats:italic>Conclusion.<\/jats:italic> T2w\u2010SI and DWI\u2010SI showed significant differences for 3.0\u2009T compared to 1.5\u2009T in all three controls, while ADCSI showed no significant differences in all three controls on both field strengths. rSI was comparable for 3.0\u2009T and 1.5\u2009T MRI in rectal cancer patients; therefore, rectal cancer patients can be assessed both at 3.0\u2009T MRI and 1.5\u2009T MRI. However, a significant DWI\u2010<jats:italic>\u2206<\/jats:italic>SI and ADC\u2010\u2206SI on 3.0\u2009T in CR might be interpreted as a better visual assessment in discriminating response to therapy compared to 1.5\u2009T. Further investigations should be performed to confirm future possible clinical application.<\/jats:p>","DOI":"10.1155\/2020\/9842732","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T23:20:25Z","timestamp":1602544825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Magnetic Resonance of Rectal Cancer Response to Therapy: An Image Quality Comparison between 3.0 and 1.5 Tesla"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-4764","authenticated-orcid":false,"given":"Damiano","family":"Caruso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-7999","authenticated-orcid":false,"given":"Marta","family":"Zerunian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-456X","authenticated-orcid":false,"given":"Domenico","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-555X","authenticated-orcid":false,"given":"Tommaso","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1862-7920","authenticated-orcid":false,"given":"Pasquale","family":"Paolantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-5692","authenticated-orcid":false,"given":"Marco","family":"Rengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-6959","authenticated-orcid":false,"given":"Davide","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-8541","authenticated-orcid":false,"given":"Riccardo","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ciolina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-2666","authenticated-orcid":false,"given":"Elena","family":"Lucertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-6901","authenticated-orcid":false,"given":"Michela","family":"Polici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2959-4493","authenticated-orcid":false,"given":"Elsa","family":"Iannicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-9991","authenticated-orcid":false,"given":"Vincenzo","family":"Tombolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-7819","authenticated-orcid":false,"given":"Andrea","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-016-0403-7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090587"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4034"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/33540239"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.2.1820431"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-017-0833-8"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-018-0978-0"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000116"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04040-X"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2323031368"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.e30"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1676-y"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.287075154"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2005.12.001"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9770-5"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3251-5"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.02.044"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5026-2"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.18.6.9821200"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.4.9530026"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.6.9609155"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27117"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2578-z"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25931"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1989-y"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/9842732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/9842732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/9842732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:48:39Z","timestamp":1735631319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/9842732"}},"subtitle":[],"editor":[{"given":"Cristina","family":"Grippaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/9842732"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9842732","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9842732"}}