{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:01:04Z","timestamp":1776193264803,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602991"],"award-info":[{"award-number":["81602991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>In Southwestern China, the root of <jats:italic>Morinda angustifolia<\/jats:italic> Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from <jats:italic>M<\/jats:italic>. <jats:italic>angustifolia<\/jats:italic> root (AEMA) in carbon tetrachloride\u2010 (CCl<jats:sub>4<\/jats:sub>\u2010) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose\u2010dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl<jats:sub>4<\/jats:sub>. At doses of 100 and 200\u2009mg\/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px) in mice exposed to CCl<jats:sub>4<\/jats:sub>. However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH). Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin\u20103\u2010methyl ether. Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl<jats:sub>4<\/jats:sub>. Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of <jats:italic>M<\/jats:italic>. <jats:italic>angustifolia<\/jats:italic>. In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.<\/jats:p>","DOI":"10.1155\/2020\/9861571","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T23:32:17Z","timestamp":1585611137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anthraquinones Extract from <i>Morinda angustifolia<\/i> Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress"],"prefix":"10.1155","volume":"2020","author":[{"given":"Rui-rong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1028","authenticated-orcid":false,"given":"Xiu-fen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-4436","authenticated-orcid":false,"given":"Chuan-li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"631","article-title":"Hepatoprotective and antioxidant potential of pycnogenol in acetaminophen-induced hepatotoxicity in rats","volume":"33","author":"Raskocis A.","year":"2018","journal-title":"Phytotherapy Research"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.01.016"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306842"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao0475"},{"key":"e_1_2_9_5_2","first-page":"221","volume-title":"Floria of China","author":"Chen T.","year":"2008"},{"key":"e_1_2_9_6_2","first-page":"429","article-title":"Isolation of colour component from the roots of Morinda angustifolia Roxb. and evaluation of its dyeing characteristics","volume":"27","author":"Bhuyan R.","year":"2002","journal-title":"Indian Journal of Fibre & Textile Research"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2008.04.008"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.02.035"},{"key":"e_1_2_9_9_2","first-page":"1","article-title":"Ethnomedicinal and aromatic plants use to health care and cooking purposes by the Singphoo Tribes of Tinsukia District of Assam, India","volume":"5","author":"Borpujari D.","year":"2015","journal-title":"International Journal of Scientific and Research Publications"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.07.024"},{"key":"e_1_2_9_11_2","first-page":"40","article-title":"Evaluation of in-vitro membrane stabilization and thrombolytic activities of Morinda angustifolia Roxb","volume":"6","author":"Islam B.","year":"2015","journal-title":"Der Pharmcia Sinica"},{"key":"e_1_2_9_12_2","first-page":"15","article-title":"In-vivo antipyretic activity of methanolic extracts of root and leaves of Morinda angustifolia Roxb","volume":"5","author":"Islam B.","year":"2015","journal-title":"IOSR Journal of Pharmacy"},{"key":"e_1_2_9_13_2","first-page":"41","article-title":"A review of common used medicinal plants and prescriptions used in Dai Minority for treating biliousness","volume":"17","author":"Dao H. 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