{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:18:59Z","timestamp":1775740739056,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:p>Objective. To unearth the clinical efficacy of tacrolimus <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <a:mtext>ointment<\/a:mtext>\n                        <a:mo>+<\/a:mo>\n                        <a:mn>3<\/a:mn>\n                        <a:mi>%<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> boric acid lotion joint Chinese angelica decoction in chronic perianal eczema. Methods. Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>38<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) underwent basic therapy with tacrolimus <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <e:mtext>ointment<\/e:mtext>\n                        <e:mo>+<\/e:mo>\n                        <e:mn>3<\/e:mn>\n                        <e:mi>%<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula> boric acid lotion, whereas those in the observation group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <g:mi>n<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>38<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) were given oral Chinese angelica decoction on the basis of the above therapy. Patient\u2019s baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated. Results. No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.023<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), anus drainage and damp score (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.041<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), skin lesion score (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.025<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>), and skin lesion area score (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.035<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.020<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) and IgE level in serum (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.003<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <u:mi>P<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.129<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group. Conclusion. With respect to tacrolimus <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <w:mtext>ointment<\/w:mtext>\n                        <w:mo>+<\/w:mo>\n                        <w:mn>3<\/w:mn>\n                        <w:mi>%<\/w:mi>\n                     <\/w:math>\n                  <\/jats:inline-formula> boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.<\/jats:p>","DOI":"10.1155\/2021\/1016108","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T20:50:35Z","timestamp":1634849435000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Efficacy of Tacrolimus <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                     <a:mtext>Ointment<\/a:mtext>\n                     <a:mo>+<\/a:mo>\n                     <a:mn>3<\/a:mn>\n                     <a:mi>%<\/a:mi>\n                  <\/a:math> Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-7695","authenticated-orcid":true,"given":"Weiwei","family":"Gao","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China"},{"name":"Department of Proctology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-4063","authenticated-orcid":true,"given":"Xueli","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University, Huai\u2019an Second People\u2019s Hospital, Huai\u2019an, Jiangsu 223002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-3211","authenticated-orcid":true,"given":"Jinxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Science and Education, Lianshui County People\u2019s Hospital, Huai\u2019an 223400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-0972","authenticated-orcid":true,"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Dermatology Department of Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-8684","authenticated-orcid":true,"given":"Yuegang","family":"Wei","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-006-0529-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-004-0046-3"},{"issue":"6","key":"3","first-page":"366","article-title":"Pruritus ani","volume":"39","author":"J. 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