{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:02:32Z","timestamp":1767168152573,"version":"build-2238731810"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["20C1586"],"award-info":[{"award-number":["20C1586"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,8,4]]},"abstract":"<jats:p>\n                    Objective. The purpose of this study was to evaluate the wound healing efficacy of oxidized regenerated cellulose (ORC)\/collagen dressing and ORC\/collagen\/silver-ORC dressings compared to standard of care or control in treatment of chronic skin wounds such as diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure injuries sore ulcers (PISUs). Methods. An electronic search was carried out in four popular databases PubMed, Scopus, Embase, and CENTRAL to identify thirteen included studies, comparing the clinical efficacy of ORC\/collagen dressings when compared to control in management of chronic skin wounds, especially DFUs, VLUs, and PISUs, and skin graft donor site wounds. Results. Consolidated data from thirteen comparative clinical studies undertaken for management of DFUs, VLUs, and PISUs showed favorable outcomes towards use of ORC\/collagen compared to other traditional and hydrocolloid foam dressings in terms of wound healing rate (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.02<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) and percentage wound relative reduction (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.003<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The time taken to achieve complete wound healing in the included studies did not show any statistical significant difference (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.24<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). There was no significant difference in adverse events between ORC\/collagen-treated group and comparative group (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.19<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. ORC\/collagen wound dressings are beneficial in terms of improved wound healing rate and percentage wound relative reduction compared to already existing traditional standard of care with non-MMP, inhibiting biomaterials such as moistened gauze, autologous growth factors, hydrocolloid foam dressings, or ovine extracellular matrix.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1058671","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T17:50:07Z","timestamp":1628099407000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Oxidized Regenerated Cellulose\/Collagen Dressing for Management of Skin Wounds: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-011X","authenticated-orcid":true,"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Wound Stoma Care, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Wound Stoma Care, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Wound Stoma Care, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Wound Stoma Care, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-248X","authenticated-orcid":true,"given":"Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Hand and Foot Surgery, The Affifiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0761"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jccw.2014.03.001","article-title":"Factors that impair wound healing","volume":"4","author":"K. 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