{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:16:13Z","timestamp":1783653373773,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["2449"],"award-info":[{"award-number":["2449"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . To investigate the association of glutathione s\u2010transferase omega 2 (GSTO2) (142N\u2009&gt;\u2009D) and transforming growth factor\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 (TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1) (869T\u2009&gt;\u2009C) gene polymorphisms on the pathogenesis of two common types of glaucoma (including primary open\u2010angle glaucoma (POAG) and chronic angle\u2010closure glaucoma (CACG)) in the Iranian population.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A total of 100 glaucoma patients (60% males and 40% females with an age mean\u2009\u00b1\u2009SD of 34.66\u2009\u00b1\u200914.25 years; 56 cases of POAG and 44 cases of CACG) were enrolled in this study. GSTO2 (142N\u2009&gt;\u2009D) and TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 (869T\u2009&gt;\u2009C) polymorphisms were evaluated by PCR\u2010based methods in patients and controls.\n                    <jats:italic>Results<\/jats:italic>\n                    . At locus GSTO2 (142N\u2009&gt;\u2009D), the odds of ND genotype with respect to DD and NN genotypes were 1.55 and 2.08 times higher in POAG and CACG patients compared to those of patients in the control group (95% CI\n                    <jats:sub>1<\/jats:sub>\n                    : 0.80\u20132.98; 95% CI\n                    <jats:sub>2<\/jats:sub>\n                    : 1.00\u20134.33) which was statistically significant in CACG patients. However, the odds of DD and NN genotypes against the reference genotype in two patients group were not statistically significant as compared to those of patients in the control group. There was a significant association between the ND genotype and male patients (OR\u2009=\u20092.28, 95% CI: 1.06\u20134.92). The analysis of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 (869T\u2009&gt;\u2009C) polymorphisms showed no significant difference between the genotypes of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 (869T\u2009&gt;\u2009C) polymorphisms in patients and control groups; however, the CT genotype of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 significantly differed between female controls and patients (OR\u2009=\u20090.42, 95% CI: 0.18\u20130.96).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The presented results revealed that there was a significant association between the ND genotype of GSTO2 and the pathogenesis of glaucoma. Furthermore, this genotype can be considered as a sex\u2010dependent genetic risk factor for the development of glaucoma. In contrast, the CT genotype of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 is suggested to be a protective genetic factor against the pathogenesis of glaucoma.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1061650","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:20:10Z","timestamp":1637706010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glutathione S\u2010Transferase Omega\u20102 and Transforming Growth Factor\u2010\n                    <i>\u03b2<\/i>\n                    1 Polymorphisms in Iranian Glaucoma Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5609-016X","authenticated-orcid":false,"given":"Shahram","family":"Bamdad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-2632","authenticated-orcid":false,"given":"Fatemeh","family":"Sanie-Jahromi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Alamolhoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-9534","authenticated-orcid":false,"given":"Nasrin","family":"Masihpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-6277","authenticated-orcid":false,"given":"Mohammad-Hossein","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_13_1_2","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley H. 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