{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:16:38Z","timestamp":1767165398791,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,11,25]]},"abstract":"<jats:p>\n                    To provide direction for clinical application and pharmaceutical exploitation, the in vitro activity of sulbactam compounds and PIP\/TAZ 8\u2009:\u20091 against clinical isolates of Gram-negative bacteria (GNB,\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>976<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) 2019. By minimal inhibitory concentrations (MICs), the resistance rate of all GNB to AMP\/SBT 2\u2009:\u20091 (56.9-100%) was significantly higher than other drugs, except the resistance rate of Acinetobacter baumannii (Aba,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>204<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) to piperacillin\/tazobactam (PIP\/TAZ 8\u2009:\u20091, 78.4%) which was close to it (76.5%). Additionally, the resistance rate of Aba to other compounds except AMP\/SBT 2\u2009:\u20091 differed greatly, but that of Klebsiella pneumonia (Kpn,\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>n<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>205<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ) varied rarely. In addition, Escherichia coli (Eco,\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>n<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>204<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ) and Kpn demonstrated low and high resistance rates, respectively. Compared with cefoperazone\/sulbactam (CPZ\/SBT 2\u2009:\u20091), PIP\/TAZ 8\u2009:\u20091 had advantage in anti-Eco (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>RR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.5<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>OR<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>2.17<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ) and anti-Kpn activity (\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>RR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.88<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mtext>OR<\/o:mtext>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>1.27<\/o:mn>\n                      <\/o:math>\n                    <\/jats:inline-formula>\n                    ), while its activity against Pseudomonas aeruginosa (Pae:\n                    <jats:inline-formula>\n                      <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>n<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>194<\/q:mn>\n                      <\/q:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mtext>RR<\/s:mtext>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.91<\/s:mn>\n                      <\/s:math>\n                    <\/jats:inline-formula>\n                    , and\n                    <jats:inline-formula>\n                      <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mtext>OR<\/u:mtext>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>1.12<\/u:mn>\n                      <\/u:math>\n                    <\/jats:inline-formula>\n                    ), Aba (\n                    <jats:inline-formula>\n                      <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mtext>RR<\/w:mtext>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>1.31<\/w:mn>\n                      <\/w:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mtext>OR<\/y:mtext>\n                        <y:mo>=<\/y:mo>\n                        <y:mn>0.41<\/y:mn>\n                      <\/y:math>\n                    <\/jats:inline-formula>\n                    ), and other Enterobacteriaceae (other Ebc:\n                    <jats:inline-formula>\n                      <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mi>n<\/ab:mi>\n                        <ab:mo>=<\/ab:mo>\n                        <ab:mn>169<\/ab:mn>\n                      <\/ab:math>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:inline-formula>\n                      <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <cb:mtext>RR<\/cb:mtext>\n                        <cb:mo>=<\/cb:mo>\n                        <cb:mn>1.40<\/cb:mn>\n                      <\/cb:math>\n                    <\/jats:inline-formula>\n                    , and\n                    <jats:inline-formula>\n                      <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <eb:mtext>OR<\/eb:mtext>\n                        <eb:mo>=<\/eb:mo>\n                        <eb:mn>0.62<\/eb:mn>\n                      <\/eb:math>\n                    <\/jats:inline-formula>\n                    ) was not better than CPZ\/SBT 2\u2009:\u20091. Although it had advantage against Eco (\n                    <jats:inline-formula>\n                      <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <gb:mtext>RR<\/gb:mtext>\n                        <gb:mo>=<\/gb:mo>\n                        <gb:mn>0.60<\/gb:mn>\n                      <\/gb:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\">\n                        <ib:mtext>OR<\/ib:mtext>\n                        <ib:mo>=<\/ib:mo>\n                        <ib:mn>1.78<\/ib:mn>\n                      <\/ib:math>\n                    <\/jats:inline-formula>\n                    ), Pae (\n                    <jats:inline-formula>\n                      <kb:math xmlns:kb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M19\">\n                        <kb:mtext>RR<\/kb:mtext>\n                        <kb:mo>=<\/kb:mo>\n                        <kb:mn>0.67<\/kb:mn>\n                      <\/kb:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <mb:math xmlns:mb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M20\">\n                        <mb:mtext>OR<\/mb:mtext>\n                        <mb:mo>=<\/mb:mo>\n                        <mb:mn>1.63<\/mb:mn>\n                      <\/mb:math>\n                    <\/jats:inline-formula>\n                    ), and Aba (\n                    <jats:inline-formula>\n                      <ob:math xmlns:ob=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M21\">\n                        <ob:mtext>RR<\/ob:mtext>\n                        <ob:mo>=<\/ob:mo>\n                        <ob:mn>0.70<\/ob:mn>\n                      <\/ob:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <qb:math xmlns:qb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M22\">\n                        <qb:mtext>OR<\/qb:mtext>\n                        <qb:mo>=<\/qb:mo>\n                        <qb:mn>2.05<\/qb:mn>\n                      <\/qb:math>\n                    <\/jats:inline-formula>\n                    ), the inhibition effect of piperacillin\/sulbactam (PIP\/SBT 2\u2009:\u20091) against Kpn (\n                    <jats:inline-formula>\n                      <sb:math xmlns:sb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M23\">\n                        <sb:mtext>RR<\/sb:mtext>\n                        <sb:mo>=<\/sb:mo>\n                        <sb:mn>0.94<\/sb:mn>\n                      <\/sb:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <ub:math xmlns:ub=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M24\">\n                        <ub:mtext>OR<\/ub:mtext>\n                        <ub:mo>=<\/ub:mo>\n                        <ub:mn>1.12<\/ub:mn>\n                      <\/ub:math>\n                    <\/jats:inline-formula>\n                    ) and other Ebc was just similar with CPZ\/SBT 2\u2009:\u20091 (\n                    <jats:inline-formula>\n                      <wb:math xmlns:wb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M25\">\n                        <wb:mtext>RR<\/wb:mtext>\n                        <wb:mo>=<\/wb:mo>\n                        <wb:mn>0.93<\/wb:mn>\n                      <\/wb:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <yb:math xmlns:yb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M26\">\n                        <yb:mtext>OR<\/yb:mtext>\n                        <yb:mo>=<\/yb:mo>\n                        <yb:mn>1.10<\/yb:mn>\n                      <\/yb:math>\n                    <\/jats:inline-formula>\n                    ). Furthermore, the anti-Eco (\n                    <jats:inline-formula>\n                      <ac:math xmlns:ac=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M27\">\n                        <ac:mtext>RR<\/ac:mtext>\n                        <ac:mo>=<\/ac:mo>\n                        <ac:mn>0.70<\/ac:mn>\n                      <\/ac:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <cc:math xmlns:cc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M28\">\n                        <cc:mtext>OR<\/cc:mtext>\n                        <cc:mo>=<\/cc:mo>\n                        <cc:mn>1.50<\/cc:mn>\n                      <\/cc:math>\n                    <\/jats:inline-formula>\n                    ), anti-Kpn (\n                    <jats:inline-formula>\n                      <ec:math xmlns:ec=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M29\">\n                        <ec:mtext>RR<\/ec:mtext>\n                        <ec:mo>=<\/ec:mo>\n                        <ec:mn>0.89<\/ec:mn>\n                      <\/ec:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <gc:math xmlns:gc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M30\">\n                        <gc:mtext>OR<\/gc:mtext>\n                        <gc:mo>=<\/gc:mo>\n                        <gc:mn>1.24<\/gc:mn>\n                      <\/gc:math>\n                    <\/jats:inline-formula>\n                    ), and anti-Pae (\n                    <jats:inline-formula>\n                      <ic:math xmlns:ic=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M31\">\n                        <ic:mtext>RR<\/ic:mtext>\n                        <ic:mo>=<\/ic:mo>\n                        <ic:mn>0.74<\/ic:mn>\n                      <\/ic:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <kc:math xmlns:kc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M32\">\n                        <kc:mtext>OR<\/kc:mtext>\n                        <kc:mo>=<\/kc:mo>\n                        <kc:mn>1.46<\/kc:mn>\n                      <\/kc:math>\n                    <\/jats:inline-formula>\n                    ) activities of ceftazidime\/sulbactam (CAZ\/SBT 1\u2009:\u20091) had a weak advantage, while its activity against Aba (\n                    <jats:inline-formula>\n                      <mc:math xmlns:mc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M33\">\n                        <mc:mtext>RR<\/mc:mtext>\n                        <mc:mo>=<\/mc:mo>\n                        <mc:mn>0.94<\/mc:mn>\n                      <\/mc:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <oc:math xmlns:oc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M34\">\n                        <oc:mtext>OR<\/oc:mtext>\n                        <oc:mo>=<\/oc:mo>\n                        <oc:mn>1.15<\/oc:mn>\n                      <\/oc:math>\n                    <\/jats:inline-formula>\n                    ) and other Ebc (\n                    <jats:inline-formula>\n                      <qc:math xmlns:qc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M35\">\n                        <qc:mtext>RR<\/qc:mtext>\n                        <qc:mo>=<\/qc:mo>\n                        <qc:mn>0.79<\/qc:mn>\n                      <\/qc:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <sc:math xmlns:sc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M36\">\n                        <sc:mtext>OR<\/sc:mtext>\n                        <sc:mo>=<\/sc:mo>\n                        <sc:mn>1.36<\/sc:mn>\n                      <\/sc:math>\n                    <\/jats:inline-formula>\n                    ) was just close to CPZ\/SBT 2\u2009:\u20091. Moreover, the inhibitory effect of PIP\/SBT 1\u2009:\u20091 against all tested clinical species was more active than CPZ\/SBT 2\u2009:\u20091, while that of CAZ\/SBT 2\u2009:\u20091 against all species of bacteria analyzed was weaker than the controls.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1175379","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T14:50:08Z","timestamp":1637851808000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["In Vitro Activity of Various Sulbactam Compounds and Piperacillin\/Tazobactam against Clinical Isolates of Different Gram-Negative Bacteria"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shunian","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuyue","family":"Zhuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-6900","authenticated-orcid":true,"given":"Chao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"National and State Healthcare-Associated Infections Progress Report","author":"CDC","year":"2016"},{"key":"2","volume-title":"Antimicrobial Resistance Surveillance Report Europe","author":"ECDC","year":"2018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.02.020"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881750"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2018.7594"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00117-14"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir475"},{"key":"8","volume-title":"Status Report on Antimicrobial Administration and Antimicrobial Resistance in China","author":"NHC","year":"2019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020077"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.4.567"},{"key":"11","volume-title":"M07Ed11, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically","author":"CLSI","year":"2018","edition":"11th"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.02.017"},{"key":"13","volume-title":"M100Ed30E, Performance Standards for Antimicrobial Susceptibility Testing","author":"CLSI","year":"2020","edition":"30th"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02039-13"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.07.014"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.07.012"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03550.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00797-10"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.05.018"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.06.005"}],"updated-by":[{"DOI":"10.1155\/2023\/9839734","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"record-id":"61099"},{"DOI":"10.1155\/2023\/9839734","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/1175379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/1175379.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/1175379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T14:50:14Z","timestamp":1637851814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/1175379\/"}},"subtitle":[],"editor":[{"given":"Osamah Ibrahim","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":20,"alternative-id":["1175379","1175379"],"URL":"https:\/\/doi.org\/10.1155\/2021\/1175379","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,25]]}}}