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In the present study, we investigated the antiproliferative effects of the treatment with the combination of paclitaxel (PAC) and all\u2010trans retinoic acid (ATRA) on ADPKD epithelial cells. Our results show that the combined treatment with 1\u2009nM PAC and 10\u2009nM ATRA significantly suppressed ADPKD cell proliferation (20%), while the treatment with ATRA or PAC alone had no such effect. Treatment with PAC and ATRA induced cell cycle arrest at the G2\/M phase and apoptosis by upregulating p53 and caspase\u20108 expression and increased the intracellular calcium (Ca<jats:sup>2+<\/jats:sup>) level possibly by enhancing Ca<jats:sup>2+<\/jats:sup> uptake via plasma membrane channels. In addition, this treatment suppressed extracellular signal\u2010regulated kinase signaling possibly through mitogen\u2010activated protein kinase phosphatase\u20101 activation. Thus, the combination of PAC and ATRA can be explored as a potential treatment regimen for ADPKD.<\/jats:p>","DOI":"10.1155\/2021\/1242916","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T02:56:03Z","timestamp":1633575363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic Antiproliferative Effects of All\u2010Trans Retinoic Acid and Paclitaxel on Autosomal Dominant Polycystic Kidney Disease Epithelial Cells"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-0683","authenticated-orcid":false,"given":"Que Thanh Thanh","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-5843","authenticated-orcid":false,"given":"Thi Xoan","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2148-4465","authenticated-orcid":false,"given":"Hyunjin","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-2179","authenticated-orcid":false,"given":"Kook-Hwan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-3580","authenticated-orcid":false,"given":"Jae Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2011.05.001"},{"key":"e_1_2_9_3_2","first-page":"61","article-title":"Autosomal dominant polycystic kidney disease: review and management update","volume":"1","author":"Mart\u00ednez V.","year":"2014","journal-title":"European Medical Journal Nephrology"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72272"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9045.1"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/368750a0"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90048-B"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21730"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2619::AID-CNCR26>3.0.CO;2-J"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-37"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406543200"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.10.4507"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.1.20"},{"key":"e_1_2_9_14_2","first-page":"150","article-title":"Retinoids as antitumor agents: a new age of biological therapy","volume":"5","author":"Kurie J. 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