{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:40:07Z","timestamp":1790872807939,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:p>The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors, remains unclear. Therefore, we sought to characterize the effects of miR-342 in endometrial stromal cell proliferation by regulating Annexin A2 (ANXA2). We first characterized the levels of miR-342 and ANXA2 in 31 cases of normal endometrium from patients with grade II-III cervical intraepithelial neoplasia or patients with hysterectomy versus ectopic endometrial tissues of 42 patients with endometriosis. miR-342 was upregulated, while ANXA2 was downregulated in ectopic endometrial tissues. Bioinformatics website and dual-luciferase reporter assay revealed that miR-342 negatively modulated ANXA2 expression. Following loss- and gain-of-function approaches, CCK-8, Transwell, and flow cytometry demonstrated that overexpression of miR-342 markedly increased cell proliferation, migration, and invasion but inhibited cell apoptotic ratio of endometrial stromal cells, which was reversed by ANXA2 elevation. Further, overexpressed miR-342 activated the PI3K\/AKT\/mTOR signaling pathway, as evidenced by upregulated levels of p-PI3K\/PI3K, p-AKT\/AKT, and p-mTOR\/mTOR. Taken together, miR-342 targets ANXA2 to activate the PI3K\/AKT\/mTOR signaling pathway, thereby promoting the malignant-like phenotype of endometrial stromal cells, highlighting miR-342 inhibition as a promising approach for the treatment of endometriosis.<\/jats:p>","DOI":"10.1155\/2021\/1328682","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T19:50:08Z","timestamp":1621281008000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6249-5999","authenticated-orcid":true,"given":"Dan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gynecology, Heilongjiang Provincial Hospital, Harbin, 150036 Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-0703","authenticated-orcid":true,"given":"Yiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heilongjiang Provincial Hospital, Harbin, 150036 Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-3926","authenticated-orcid":true,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Heilongjiang Provincial Hospital, Harbin, 150036 Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-0444","authenticated-orcid":true,"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Heilongjiang Provincial Hospital, Harbin, 150036 Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28666"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaz006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2019.01.005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00242"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010093"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.050"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0480-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5578"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.032"},{"issue":"6","key":"11","first-page":"2883","article-title":"Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K\/AKT\/mTOR signaling","volume":"34","author":"P. 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