{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:22:10Z","timestamp":1778858530367,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":248,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C4002594"],"award-info":[{"award-number":["2020R1A2C4002594"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07048092"],"award-info":[{"award-number":["NRF-2018R1D1A1B07048092"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Although hippocampal changes due to noise\u2010induced hearing loss have been suggested, little is known about the miRNA levels due to these hippocampal changes. Three\u2010week\u2010old Sprague\u2010Dawley rats were divided into noise and control groups (<jats:italic>n<\/jats:italic> = 20 per group). The noise group rats were exposed to white Gaussian noise (115\u2009dB SPL, 4 hours per day) for three days. One day after noise exposure, the hippocampi of rats were harvested and miRNA expressions were analyzed using the Affymetrix miRNA 4.0 microarray (<jats:italic>n<\/jats:italic> = 6 per group). The predicted target genes of each miRNA were retrieved, and the pathways related to the predicted target genes were analyzed. miR\u2010758\u20105p, miR\u2010210\u20105p, miR\u2010370\u20105p, miR\u2010652\u20105p, miR\u20103544, miR\u2010128\u20101\u20105p, miR\u2010665, miR\u2010188\u20105p, and miR\u2010874\u20105p expression increased in the hippocampal tissue of the noise group compared to that in the control group. The overlapping predicted target genes included <jats:italic>Bend4<\/jats:italic>, <jats:italic>Creb1<\/jats:italic>, <jats:italic>Adcy6<\/jats:italic>, <jats:italic>Creb5<\/jats:italic>, <jats:italic>Kcnj9<\/jats:italic>, and <jats:italic>Pten<\/jats:italic>. The pathways related to these genes were the estrogen signaling pathway, vasopressin\u2010regulated water reabsorption, thyroid hormone synthesis, aldosterone synthesis and secretion, insulin secretion, circadian entrainment, insulin resistance, cholinergic synapse, dopaminergic synapse, cGMP\u2010PKG signaling pathway, cAMP signaling pathway, PI3K\u2010Akt signaling pathway, TNF signaling pathway, and AMPK signaling pathway. miR\u2010448\u20103p, miR204\u20105p, and miR\u2010204\u20103p expression decreased in the hippocampal tissue of the noise group compared to that in the control group. The overlapping predicted target genes of these three miRNAs were <jats:italic>Rps6kas<\/jats:italic>, <jats:italic>Nfactc3<\/jats:italic>, <jats:italic>Rictor<\/jats:italic>, <jats:italic>Spred1<\/jats:italic>, <jats:italic>Cdh4<\/jats:italic>, <jats:italic>Cdh6<\/jats:italic>, <jats:italic>Dvl3<\/jats:italic>, and <jats:italic>Rcyt1b<\/jats:italic>. Pathway analysis suggested that the Wnt signaling pathway is related to <jats:italic>Dvl3<\/jats:italic> and <jats:italic>Nfactc3<\/jats:italic>. Noise\u2010induced hearing loss dysregulates miR\u2010758\u20105p, miR210\u20105p, miR370\u20105p, miR\u2010652\u20105p, miR\u20103544, miR\u2010128\u20101\u20105p, miR\u2010665, miR\u2010188\u20105p, miR\u2010874\u20105p, miR\u2010448\u20103p, miR\u2010204\u20105p, miR\u2010204\u20103p, and miR\u2010140\u20105p expression in the hippocampus. These miRNAs have been predicted to be associated with hormonal, inflammatory, and synaptic pathways.<\/jats:p>","DOI":"10.1155\/2021\/1377195","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T01:35:05Z","timestamp":1630978505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MicroRNA Dysregulation in the Hippocampus of Rats with Noise\u2010Induced Hearing Loss"],"prefix":"10.1155","volume":"2021","author":[{"given":"Seungmin","family":"Ha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Woon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang 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