{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:05:49Z","timestamp":1778432749751,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170560"],"award-info":[{"award-number":["BK20170560"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703773"],"award-info":[{"award-number":["81703773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Lung injury was the common and serious complication of sepsis, a systemic inflammatory response syndrome caused by severe infections. Chinese medicine had unique advantages in attenuating inflammatory response, such as Zuojinfang (ZJF). ZJF was a classical compound herb formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6\u2009:\u20091. In this paper, 15 ingredients in ZJF were identified and 8 of them absorbed into rat\u2019s serum were quantified by HPLC\u2010MS\/MS. Subsequently, sepsis\u2010induced lung injury model was replicated in rats by cecal ligation and puncture. 60 SD rats were randomly divided into 6 groups (<jats:italic>n<\/jats:italic> = 10): control group (CON), sham group (Sham), model group (MOD), ZJF low\u2010dose group (ZJF\u2010L), ZJF high\u2010dose group (ZJF\u2010H), and prednisolone group (PNSL). Within the next 24\u2009h, the levels of inflammatory factors, correlation between active ingredients and inflammatory cytokines, the pathological changes of lung tissue, and protein expression of the JAK1\/STAT3 signaling pathways were analyzed one by one. Finally, the concentration order of components absorbed in rat serum was berberine\u2009&gt;\u2009palmatine\u2009&gt;\u2009jatrorrhizine\u2009&gt;\u2009coptisine\u2009&gt;\u2009evodin\u2009&gt;\u2009chlorogenic acid\u2009&gt;\u2009evodiamine. Compared with the MOD group, the TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106, and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in the ZJF\u2010H group were significantly reduced (<jats:italic>p<\/jats:italic> &lt; 0.05). Moreover, the TNF\u2010<jats:italic>\u03b1<\/jats:italic> decreased significantly accompanied by the increase of berberine, chlorogenic acid, jatrorrhizine, palmatine, evodin, and evodiamine in serum (negative correlation, <jats:italic>p<\/jats:italic> &lt; 0.05). Compared with the MOD, the area of lung injury, the expressions of JAK1, p\u2010JAK1, STAT3, and p\u2010STAT3 were significantly decreased under the treatment of ZJF (<jats:italic>p<\/jats:italic> &lt; 0.05). Therefore, downregulating the JAK1\/STAT3 signaling pathways was a potential avenue of ZJF in reversing lung injury induced by sepsis.<\/jats:p>","DOI":"10.1155\/2021\/1419631","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T11:21:21Z","timestamp":1610450481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effect of Zuojin Fang on Lung Injury Induced by Sepsis through Downregulating the JAK1\/STAT3 Signaling 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