{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T14:46:52Z","timestamp":1747666012689,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Osteoporosis"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Purpose. To assess site-specific volumetric bone and muscle changes, as well as demographic and biochemical changes, in postmenopausal women with a low-energy distal forearm fracture. Methods. In a cross-sectional case-control study, postmenopausal women with a distal forearm fracture were compared with age- and gender-matched controls. In total, 203 postmenopausal women (104 cases and 99 controls), with a mean age of 65 years, were included. Measurements included peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) as well as blood sampling and questionnaires. Results. Forearm trabecular volumetric BMD and total BMD assessed with pQCT were significantly lower in fracture cases compared to controls (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Significantly higher cross-sectional area, lower cortical BMD, and lower cortical thickness were seen in women with fracture (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.033<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, and <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, respectively). Postmenopausal women with fracture had significantly lower hip and spine areal BMD assessed with DXA (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Activity level was higher and a history of falling was more frequent in women with fracture (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.019<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, respectively). Vertebral fracture was observed in 24 women (22%) with a distal forearm fracture. Muscle area, muscle density, PTH, and 25OHD did not differ between fracture cases and controls. Conclusion. A distal forearm fracture was associated with site-specific and central bone changes. Postmenopausal women with fracture had a larger bone area in combination with a thinner cortex and lower site-specific total BMD. In addition, women with fracture had a higher activity level, an increased occurrence of previous fall accidents, and a high prevalence of vertebral fractures. Forearm muscle composition, PTH, and 25OHD were not associated with forearm fracture. Fracture preventive measures following a low-energy distal forearm fracture seem beneficial.<\/jats:p>","DOI":"10.1155\/2021\/1578543","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T05:10:42Z","timestamp":1633065042000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Site-Specific Volumetric Skeletal Changes in Women with a Distal Forearm Fracture"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-9655","authenticated-orcid":true,"given":"Axel","family":"Wihlborg","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Department of Orthopedics, K54, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Endocrinology, Metabolism & Diabetes, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Department of Endocrinology, Metabolism & Diabetes, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8061-7163","authenticated-orcid":true,"given":"Paul","family":"Gerdhem","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Department of Orthopedics, K54, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00296650"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050172"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050048"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.010"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100160517"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1380-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3160-8"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1047-2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080704"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071108"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170063"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7041.1254"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.6.587"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1947"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa022464"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.2.248"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(98)00048-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190104"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3106-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1745-8"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701207575"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096547"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1177\/1403494813483215"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2559"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110719"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.03.024"}],"container-title":["Journal 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