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This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: \u201c<jats:italic>Lasia spinosa<\/jats:italic>,\u201d then combined with \u201cethnopharmacological use,\u201d \u201cphytochemistry,\u201d and \u201cpharmacological activity.\u201d This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological mechanisms. The research results showed that <jats:italic>L. spinosa<\/jats:italic> contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti\u2010inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, <jats:italic>L. spinosa<\/jats:italic> can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.<\/jats:p>","DOI":"10.1155\/2021\/1602437","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T23:20:43Z","timestamp":1640733643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<i>Lasia spinosa<\/i> Chemical Composition and Therapeutic Potential: A Literature\u2010Based Review"],"prefix":"10.1155","volume":"2021","author":[{"given":"Rajib","family":"Hossain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Quispe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-7920","authenticated-orcid":false,"given":"Jes\u00fas","family":"Herrera-Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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