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Accumulating evidence has indicated that oxidative stress plays a vital role in vitiligo via directly destructing melanocytes and triggering inflammatory response that ultimately undermines melanocytes. Folic acid (FA), an oxidized form of folate with high bioavailability, exhibits potent antioxidant properties and shows therapeutic potential in multiple oxidative stress\u2010related diseases. However, whether FA safeguards melanocytes from oxidative damages remains unknown. In this study, we first found that FA relieved melanocytes from H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced abnormal growth and apoptosis. Furthermore, FA enhanced the activity of antioxidative enzymes and remarkably reduced intracellular ROS levels in melanocytes. Subsequently, FA effectively activated nuclear factor E2\u2010related factor 2 (Nrf2) pathway, and Nrf2 knockdown blocked the protective effects of FA on H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010treated melanocytes. Additionally, FA inhibited the production of proinflammatory HMGB1 in melanocytes under oxidative stress. Taken together, our findings support the protective effects of FA on human melanocytes against oxidative injury via the activation of Nrf2 and the inhibition of HMGB1, thus indicating FA as a potential therapeutic agent for the treatment of vitiligo.<\/jats:p>","DOI":"10.1155\/2021\/1608586","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T23:05:26Z","timestamp":1638918326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Folic Acid Protects Melanocytes from Oxidative Stress via Activation of Nrf2 and Inhibition of 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