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Our study established an anxiety rat model using chronic restraint stress (CRS) and assessed these animals using the open\u2010field test, elevated plus\u2010maze test, and light\u2010dark box test. Jie\u2010Yu\u2010He\u2010Huan capsule (JYHH), a Chinese medicine formula, was used as a preventative drug. The HPA axis\u2010mediated release of corticotropin\u2010releasing hormone, adrenocorticotropic hormone, and corticosterone from the hypothalamus was tested. In the hippocampus and prefrontal cortex, concentrations of 5\u2010HT and its metabolite 5\u2010hydroxyindoleacetic acid, as well as monoamine oxidase A, glucocorticoid receptor, and 5\u2010HT1A receptor expression levels, were measured. Furthermore, we examined protein and mRNA expression of cAMP\u2010PKA\u2010CREB\u2010BDNF pathway components. The results showed that JYHH had a significant preventative effect on the anxiety\u2010like behaviour induced by CRS and prevented abnormal changes in the HPA axis and 5\u2010HT system. 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This might be the underlying molecular mechanism of the antianxiety effect of JYHH, which could provide a new clinical target for preventative anxiolytic drugs for chronic stress.<\/jats:p>","DOI":"10.1155\/2021\/1703981","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T22:41:59Z","timestamp":1633387319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Jie\u2010Yu\u2010He\u2010Huan Capsule Ameliorates Anxiety\u2010Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP\/PKA\/CREB\/BDNF Signalling 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