{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T18:29:10Z","timestamp":1779042550792,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,24]]},"abstract":"<jats:p>The current study aimed to determine the protective effect of P. reticulatus on ethanol-induced gastric ulcer. For this purpose, thirty-six Sprague-Dawley rats were divided into six groups. The first group served as normal control, while, in other five groups, absolute ethanol was used to induce gastric ulcer. Group II served as a diseased group, while groups III, IV, and V were treated with methanol extract, ethyl acetate fraction, and n-hexane fraction, respectively, in a dose of 400\u2009mg\/kg bodyweight. Group VI was given omeprazole in a dose 20\u2009mg\/kg bodyweight. The stomachs were removed, ulcer score was evaluated, and histopathological examination of gastric lumen was conducted. Total acidity and pH values were determined in gastric juice. TNF-\u03b1 and IL-8 mRNA expressions levels were determined using the reverse transcription real-time PCR method. The data indicated that P. reticulatus protected against gastric ulcer, which was evident by attenuation of ulcer score. The pretreatment with P. reticulatus raised the gastric pH and improved all evaluated histopathological parameters such as ulcer score, erosion score, hemorrhage score, fibrinoid necrosis score, inflammatory infiltrate score, and edema score. P. reticulatus significantly reduced mRNA expression levels of TNF-\u03b1 and IL-8. In conclusion, P. reticulatus possess antiulcer property which might be attributed to downregulation of TNF-\u03b1 and IL-8 expression levels.<\/jats:p>","DOI":"10.1155\/2021\/1734752","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T17:35:08Z","timestamp":1632591308000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-\u03b1 Levels"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hafsa","family":"Izhar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore Campus, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-830X","authenticated-orcid":true,"given":"Arham","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University, Jail Road, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Health Sciences, Lahore, Punjab, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Mobashar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore Campus, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Shoaib","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Centre for Research in Molecular Medicine, The University of Lahore, Lahore Campus, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20090201-25"},{"key":"2","volume-title":"Harrison\u2019s Manual of Medicine","author":"A. 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