{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:32:28Z","timestamp":1791379948047,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2021,9,6]]},"abstract":"<jats:p>Introduction. Medical cannabis (MC) is becoming increasingly popular for the treatment of chronic pain conditions. In this study, we evaluated the effect of MC treatment on pain level and quality of sleep of patients with different medical conditions at the rheumatology clinic. Methods. Patients licensed for the use of MC at the rheumatology clinics at different settings were located and contacted. Their demographic and clinical parameters were documented, including type of medical cannabis consumed, way of consumption, and current monthly consumed amount. These patients were contacted by phone and asked about the effect on pain level and quality of sleep. Results. A total of 351 patients were located, and 319 completed the questionnaire. Mean age was 46\u2009\u00b1\u200912 years, 76% were female, 82% had fibromyalgia, \u223c9% had mechanical problems, \u223c4% had inflammatory problems, \u223c4% had neurological problems, and \u223c1% had other problems. The average monthly consumed dose of MC was 31, 35, 36, and 32\u2009g, with mean pain level reduction of 77%, 82%, 83%, and 57%, and mean sleep quality improvement of 78%, 71%, 87%, and 76% among patients with fibromyalgia, mechanical, neuropathic, and inflammatory problems, respectively. Mean THC and CBD contents were 18.38%\u2009\u00b1\u20094.96 and 2.62%\u2009\u00b1\u20094.87, respectively. The THC concentration, duration of MC consumption, and MC consumption dose had independent significant correlations with pain reduction while only the duration of MC consumption had an independent significant correlation with sleep quality improvement. Conclusions. MC had a favorable effect on pain level and quality of sleep among all spectrums of problems at the rheumatology clinic.<\/jats:p>","DOI":"10.1155\/2021\/1756588","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T15:05:06Z","timestamp":1631027106000},"page":"1-6","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-8575","authenticated-orcid":true,"given":"George","family":"Habib","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Laniado Hospital, Netanya, Israel"},{"name":"Rheumatology Clinic, Nazareth Hospital, Nazareth, Israel"},{"name":"Faculty of Medicine, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-4874","authenticated-orcid":true,"given":"Fadi","family":"Khazin","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Lady Davis Medical Center, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-6034","authenticated-orcid":true,"given":"Suheil","family":"Artul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel"},{"name":"Department of Radiology, Nazareth Hospital, Nazareth, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0862-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/rhu.0000000000000702"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060807"},{"key":"4","first-page":"53","article-title":"Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study","volume":"38","author":"V. Giorgi","year":"2020","journal-title":"Clinical and Experimental Rheumatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00035-19"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.06.005"},{"key":"7","article-title":"Why are we still using opioids for osteoarthritis?","volume":"74","author":"K. Yip","year":"2019","journal-title":"International Journal of Clinical Practice"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0685-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1089\/can.2018.0027"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.03.008"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/wnf.0000000000000246"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-019-1243-x"},{"issue":"10","key":"13","first-page":"659","article-title":"Prevalence of fibromyalgia at the rheumatology clinic","volume":"22","author":"G. Habib","year":"2020","journal-title":"The Israel Medical Association Journal"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2016-0012"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.12.024"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7829427"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.18-0208"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2174\/1573397111666150619095007"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205781"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.10.016"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1089\/can.2016.0009"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0775-9"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080827"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.035"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1089\/can.2015.0001"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/ar2401"},{"key":"27","first-page":"13","article-title":"Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single center study","volume":"37","author":"M. Yassin","year":"2019","journal-title":"Clinical & Experimental Rheumatology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000006293"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001386"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5234943"},{"key":"31","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1211\/0022357022304","article-title":"Medicinal cannabis: is delta9-tetrahydrocannabinol necessary for all its effects?","volume":"55","author":"J. D. Wilkinson","year":"2003","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56050237"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-61663-2_11"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2021\/1756588.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2021\/1756588.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2021\/1756588.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T15:05:12Z","timestamp":1631027112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prm\/2021\/1756588\/"}},"subtitle":[],"editor":[{"given":"Anna Maria","family":"Aloisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,6]]},"references-count":33,"alternative-id":["1756588","1756588"],"URL":"https:\/\/doi.org\/10.1155\/2021\/1756588","relation":{},"ISSN":["1918-1523","1203-6765"],"issn-type":[{"value":"1918-1523","type":"electronic"},{"value":"1203-6765","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,6]]}}}