{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:08:27Z","timestamp":1791871707791,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["LTMC202003"],"award-info":[{"award-number":["LTMC202003"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["LTMC201909"],"award-info":[{"award-number":["LTMC201909"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["cstc2016jcyjA0020"],"award-info":[{"award-number":["cstc2016jcyjA0020"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600139"],"award-info":[{"award-number":["31600139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Human Parainfluenza Virus Type 3 (HPIV3) is one of the main pathogens that cause acute lower respiratory tract infections in infants and young children. However, there are currently no effective antiviral drugs and vaccines. Herein, we found that a natural compound, curcumin, inhibits HPIV3 infection and has antiviral effects on entry and replication of the virus life cycle. Immunofluorescence and western blotting experiments revealed that curcumin disrupts F\u2010actin and inhibits viral inclusion body (IB) formation, thus inhibiting virus replication. Curcumin can also downregulate cellular PI4KB and interrupt its colocalization in viral IBs. This study verified the antiviral ability of curcumin on HPIV3 infection and preliminarily elucidated its influence on viral replication, providing a theoretical basis for antiviral drug development of HPIV3 and other parainfluenza viruses.<\/jats:p>","DOI":"10.1155\/2021\/1807293","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T05:05:13Z","timestamp":1628571913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Curcumin Inhibits Replication of Human Parainfluenza Virus Type 3 by Affecting Viral Inclusion Body Formation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-6183","authenticated-orcid":false,"given":"Chaoliang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-6534","authenticated-orcid":false,"given":"Kehan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-6436","authenticated-orcid":false,"given":"Guangchao","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-9402","authenticated-orcid":false,"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-7871","authenticated-orcid":false,"given":"Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3201-0268","authenticated-orcid":false,"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-8360","authenticated-orcid":false,"given":"Guangyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.32"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0685-2"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00042-19"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.11.034"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(92)90102-f"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.59.3.646-654.1986"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60794-0"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01565-13"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10030125"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01802-16"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00095"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.037"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.052"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.08.016"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1076"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1997.tb06761.x"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.12.007"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)98514-a"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.12.019"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.03.014"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.04.067"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062482"},{"key":"e_1_2_10_23_2","doi-asserted-by":"crossref","unstructured":"QinY. LinL. ChenY. WuS. SiX. WuH. ZhaiX. WangY. TongL. PanB. ZhongX. WangT. ZhaoW. andZhongZ. Curcumin inhibits the replication of enterovirus 71 _in vitro_ 2014 4 no. 4 284\u2013294 https:\/\/doi.org\/10.1016\/j.apsb.2014.06.006 26579397.","DOI":"10.1016\/j.apsb.2014.06.006"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5nr07918g"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7nr06520e"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.4.2655-2662.1998"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0029(19991015)47:2<114::aid-jemt4>3.0.co;2-e"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00479"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121228"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.126888"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304299"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12503"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21101401"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.09.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/1807293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/1807293.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/1807293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T14:21:06Z","timestamp":1735654866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/1807293"}},"subtitle":[],"editor":[{"given":"Emilia","family":"Lecuona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/1807293"],"URL":"https:\/\/doi.org\/10.1155\/2021\/1807293","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1807293"}}