{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:18:37Z","timestamp":1785568717011,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    . To assess the efficacy and safety of accelerated corneal cross\u2010linking in the treatment of pediatric keratoconus.\n                    <jats:italic>Method<\/jats:italic>\n                    . In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross\u2010linking. Treatment was delivered at 10\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    for 9 minutes with a total dose of 5.4\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow\u2010up duration of 24 months were included in the study.\n                    <jats:italic>Results<\/jats:italic>\n                    . Mean\u2009\u00b1\u2009standard deviation age was 15.41\u2009\u00b1\u20092.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56\u2009\u00b1\u20090.28 to 0.42\u2009\u00b1\u20090.29 logMAR (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0003), and corrected distance visual acuity improved significantly from 0.34\u2009\u00b1\u20090.23 to 0.28\u2009\u00b1\u20090.22 logMAR (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.014). The mean manifest refraction spherical equivalent value was significantly reduced (\u22120.59\u2009\u00b1\u20090.95\u2009D,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0024). While mean flat keratometry and steep keratometry values were not significantly altered (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97\u2009\u00b1\u20095.24\u2009D preoperatively to 55.84\u2009\u00b1\u20095.37\u2009D at 24 months postoperatively (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.003). Maximum keratometry had progressed by &gt;1\u2009D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Our 24\u2010month follow\u2010up demonstrated that accelerated corneal cross\u2010linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1851883","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T09:20:32Z","timestamp":1637227232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Outcomes of Accelerated Corneal Cross\u2010Linking for Pediatric Keratoconus"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-8153","authenticated-orcid":false,"given":"Abdelrahman","family":"Salman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-3698","authenticated-orcid":false,"given":"Taym","family":"Darwish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-2853","authenticated-orcid":false,"given":"Marwan","family":"Ghabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-1720","authenticated-orcid":false,"given":"Obeda","family":"Kailani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-8377","authenticated-orcid":false,"given":"Hussam","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-2037","authenticated-orcid":false,"given":"Rafea","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(97)00119-7"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000491"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20121011-01"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0699-8"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000408"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31820143d1"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.10.028"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20140527-03"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2011.12.012"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116070"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.01.002"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20121011-05"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e3180334f78"},{"key":"e_1_2_11_14_2","unstructured":"UrkudeJ. 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