{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:17:15Z","timestamp":1791688635529,"version":"4.3.4"},"reference-count":111,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":245,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Graphic Era University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    The genus\n                    <jats:italic>Diplazium<\/jats:italic>\n                    (family: Athyriaceae) comprises approximately 350 species of pteridophytes\n                    <jats:italic>. Diplazium esculentum<\/jats:italic>\n                    (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub\u2010Himalayan communities. According to the literature analysis,\n                    <jats:italic>D. esculentum<\/jats:italic>\n                    was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of\n                    <jats:italic>D. esculentum<\/jats:italic>\n                    were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of\n                    <jats:italic>D. esculentum<\/jats:italic>\n                    . The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of\n                    <jats:italic>D. esculentum<\/jats:italic>\n                    , but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on\n                    <jats:italic>D. esculentum<\/jats:italic>\n                    and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as \u201c\n                    <jats:italic>Diplazium esculentum,<\/jats:italic>\n                    bioactive compounds, biological activities and health benefits\u201d from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of\n                    <jats:italic>D. esculentum in vitro\/in vivo<\/jats:italic>\n                    , and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1917890","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T16:21:34Z","timestamp":1630686094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Diplazium esculentum<\/i>\n                    (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-5169","authenticated-orcid":false,"given":"Prabhakar","family":"Semwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Painuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik M.","family":"Painuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Antika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba Boyunegmez","family":"Tumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Thapliyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-4695","authenticated-orcid":false,"given":"Mohammed M.","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi Durna","family":"Da\u015ftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2018-2406","authenticated-orcid":false,"given":"Seyed Abdulmajid","family":"Ayatollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anka Trajkovska","family":"Petkoska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2004.03.005"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","unstructured":"AmnaU.andMardinaV. 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