{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:16:41Z","timestamp":1767165401296,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation of Jiangxi Provincial Health Department","award":["20201100"],"award-info":[{"award-number":["20201100"]}]},{"name":"Foundation of Jiangxi Provincial Health Department","award":["81960101"],"award-info":[{"award-number":["81960101"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20201100"],"award-info":[{"award-number":["20201100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960101"],"award-info":[{"award-number":["81960101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:p>\n                    Objective. To find risk markers and develop new clinical predictive models for the differential diagnosis of hand-foot-and-mouth disease (HFMD) with varying degrees of disease. Methods. 19766 children with HFMD and 64 clinical indexes were included in this study. The patients included in this study were divided into the mild patients\u2019 group (mild) with 12292 cases, severe patients\u2019 group (severe) with 6508 cases, and severe patients with respiratory failure group (severe-RF) with 966 cases. Single-factor analysis was carried out on 64 indexes collected from patients when they were admitted to the hospital, and the indexes with statistical differences were selected as the prediction factors. Binary multivariate logistic regression analysis was used to construct the prediction models and calculate the adjusted odds ratio (OR). Results. SP, DP, NEUT#, NEUT%, RDW-SD, RDW-CV, GGT, CK\/CK-MB, and Glu were risk markers in mild\/severe, mild\/severe-RF, and severe\/severe-RF. Glu was a diagnostic marker for mild\/severe-RF (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>AUROC<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.80<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    , 95% CI: 0.78-0.82); the predictive model constructed by temperature, SP, MOMO%, EO%, RDW-SD, GLB, CRP, Glu, BUN, and Cl could be used for the differential diagnosis of mild\/severe (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>AUROC<\/c:mtext>\n                        <c:mo>&gt;<\/c:mo>\n                        <c:mn>0.84<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ); the predictive model constructed by SP, age, NEUT#, PCT, TBIL, GGT, Mb, \u03b22MG, Glu, and Ca could be used for the differential diagnosis of severe\/severe-RF (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>AUROC<\/e:mtext>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.76<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. By analyzing clinical indicators, we have found the risk markers of HFMD and established suitable predictive models.\n                  <\/jats:p>","DOI":"10.1155\/2021\/1923636","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T15:05:17Z","timestamp":1630422317000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Development and Validation of Diagnostic Models for Hand-Foot-and-Mouth Disease in Children"],"prefix":"10.1155","volume":"2021","author":[{"given":"Feng","family":"Zhuo","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Center, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuoya","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiying","family":"Hu","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Center, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8225-1350","authenticated-orcid":true,"given":"Shouhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Affiliated Children\u2019s Hospital of Nanchang University, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-2352","authenticated-orcid":true,"given":"Qiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jiangxi Provincial Children\u2019s Hospital, Nanchang, Jiangxi 330006, China"},{"name":"Department of General Surgery, The Affiliated Children\u2019s Hospital of Nanchang University, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411309"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001137"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70975-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2009.05.017"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7748\/paed.17.1.32.s27"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-019-02898-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.9845"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819002279"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011355"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.2.174"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1006\/jmps.1999.1277"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2751457"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.09.020"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.907929"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065585"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087916"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5169-3"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.482"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16521-z"}],"updated-by":[{"DOI":"10.1155\/2023\/9892018","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"record-id":"47327"},{"DOI":"10.1155\/2023\/9892018","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000}}],"container-title":["Disease 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