{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:00:16Z","timestamp":1784304016213,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473790"],"award-info":[{"award-number":["81473790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,11,29]]},"abstract":"<jats:p>Visceral hypersensitivity (VH) is the predominant pathogenesis of functional dyspepsia (FD). Duodenal hypersensitivity along with nausea further reduces the comfort level in gastric balloon dilatation and inhibits gastric receptive relaxation. The potential mechanism behind electroacupuncture- (EA-) mediated alleviation of VH has not been elucidated. In an FD rat model with tail clamping stress, iodine acetamide (IA) induced VH. The rats were treated with EA with or without PAR2 antagonist FSLLRY-NH2, and the body weight, gastric sensitivity, compliance, and gastrointestinal motility were determined. Mast cells and activated degranulation were stained with toluidine blue (TB) staining and visualized under a transmission electron microscope (TEM). Immunofluorescence was used to detect the expression of PAR2, PKC, and TRPV1 in the duodenum and dorsal root ganglion (DRG) and that of CGRP, SP in DRG, and c-fos in the spinal cord. EA alone and EA\u2009+\u2009antagonist enhanced the gastrointestinal motility but diminished the expression of TRPV1, CGRP, SP, and c-fos-downstream of PAR2\/PKC pathway and alleviated VH in FD rats. However, there was no obvious superposition effect between the antagonists and EA\u2009+\u2009antagonists. The effect of EA alone was better than that of antagonists and EA\u2009+\u2009antagonists 2 alone. EA-induced amelioration of VH in FD rats was mediated by TRPV1 regulation through PAR2\/PKC pathway. This protective mechanism involved several pathways and included several targets.<\/jats:p>","DOI":"10.1155\/2021\/1975228","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T18:35:08Z","timestamp":1638210908000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Electroacupuncture Regulates TRPV1 through PAR2\/PKC Pathway to Alleviate Visceral Hypersensitivity in FD Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-9181","authenticated-orcid":true,"given":"Yong-li","family":"Han","sequence":"first","affiliation":[{"name":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei 430061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-432X","authenticated-orcid":true,"given":"Xing-ming","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine, Huangjiahu Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-9465","authenticated-orcid":true,"given":"Hong-xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Acumoxa, Wuhan Intergrated TCM & Western Medicine Hospital, Wuhan, Hubei 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-3471","authenticated-orcid":true,"given":"Song","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei 430061, China"},{"name":"Second People\u2019s Hospital of Jingzhou, Jingzhou, Hubei 434099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-0263","authenticated-orcid":true,"given":"Liang-yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Treatment Center, Second Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000278"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318536"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.052605"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04270.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00900.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309151"},{"key":"9","first-page":"311","article-title":"Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases","volume":"43","author":"S. 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