{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:16:41Z","timestamp":1767165401277,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baoding Science and Technology Planning Project","award":["2041ZF228"],"award-info":[{"award-number":["2041ZF228"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:p>Peritoneal dialysis is one of the main renal replacement treatments. However, long-term peritoneal dialysis keeps the peritoneum in contact with the sugar-containing nonphysiological peritoneal fluid, which leads to recurrent peritonitis, peritoneal fibrosis, and failure of ultrafiltration. Transforming growth factor-\u03b21 (TGF-\u03b21), related cytokines, and inflammatory factors are closely related to peritoneal fibrosis. Sulodexide (SLX) is a new type of glycosaminoglycan preparation, which is involved in the formation of an anionic charge barrier and can maintain the selective permeability of vascular endothelial cells. In this study, the innovative analysis of SLX specifically prevents the process of peritoneal dialysis peritoneal fibrosis by downregulating the expression of TGF-\u03b21 and its signaling pathway molecules. We randomly divided 30 rats into three groups. The blank control group received no treatment. The peritoneal dialysis model group was injected with 4.25% peritoneal dialysate (PDF) 20\u2009ml daily, and the SLX group was injected with 4.25% PDF 20\u2009ml\u2009+\u2009sulodexide (SLX) 20\u2009mg\/kg daily. After 8 weeks of dialysis, the rats were sacrificed, and the peritoneal function test was performed to determine the amount of glucose transport and ultrafiltration. The thickness of peritoneal per unit area was observed under high magnification. The level of inflammation in peritoneal tissue and the expression of TGF-\u03b21\/Smad were detected. The results showed that SLX can significantly improve peritoneal tissue thickening and inflammation, can downregulate the expression of TGF-\u03b21, Smad2, Smad3, and Smad7 in peritoneal tissue, and improve the progression of peritoneal fibrosis.<\/jats:p>","DOI":"10.1155\/2021\/2052787","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T18:20:07Z","timestamp":1630347607000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Sulodexide Prevents Peritoneal Fibrosis by Downregulating the Expression of TGF-\u03b21 and Its Signaling Pathway Molecules"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-9503","authenticated-orcid":true,"given":"Zhiqiang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Renal Disease, People\u2019s Hospital of Tang County (The Fourth Central Hospital of Baoding City), Baoding, Hebei 072350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Renal Disease, People\u2019s Hospital of Tang County (The Fourth Central Hospital of Baoding City), Baoding, Hebei 072350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Traditional Chinese Medicine Hospital of Wangdu County, Baoding, Hebei 072450, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Renal Disease, People\u2019s Hospital of Tang County (The Fourth Central Hospital of Baoding City), Baoding, Hebei 072350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Renal Disease, People\u2019s Hospital of Tang County (The Fourth Central Hospital of Baoding City), Baoding, Hebei 072350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000517349"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254931"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.52547\/ijkd.5959"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00149.2020"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12752"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.02380218"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3231647"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106064"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14029"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.12.023"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68495-0"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55557-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.12.030"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14324"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/172038"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02270-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3594630"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.02.025"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0687-2"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820917855"},{"issue":"145","key":"21","first-page":"271","article-title":"MicroRNAs in peritoneal fibrosis: a systematic review","volume":"26","author":"K. 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