{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:33Z","timestamp":1787678373762,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Veterinary Medicine"],"published-print":{"date-parts":[[2021,9,6]]},"abstract":"<jats:p>Case Description. A two-month-old, female, Aberdeen-Angus calf was presented for congenital cataracts and blindness in both eyes (OU). The dam had a reported history of visual defects (not specified) and had produced other affected calves (per owner history). Ophthalmic examination revealed mature bilateral cataracts, attenuation of the iridic granules, persistent pupillary membranes, and dyscoric pupils. Additionally, the calf had a poor body condition, prognathism, dome-shaped head, excessive nasal drainage, limb contracture, and fever. Histopathology of both eyes revealed lenticular degeneration (congenital cataracts), retinal dysplasia, and optic nerve hypoplasia. BVDV IHC detected antigen within only the left eye (OS), consisting of intrahistiocytic and endothelial immunoreactivity within the ciliary body, iris, and choroid. No BVDV immunoreactivity could be detected in the right eye (OD). This case highlights the unique ocular changes present in in utero BVDV infection of cattle with a different immunohistochemical staining profile than previously described.<\/jats:p>","DOI":"10.1155\/2021\/2064103","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T18:20:09Z","timestamp":1631038809000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Congenital Cataracts and Microphakia with Retinal Dysplasia and Optic Nerve Hypoplasia in a Calf"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-046X","authenticated-orcid":true,"given":"Christopher L.","family":"Siepker","sequence":"first","affiliation":[{"name":"Iowa State University Veterinary Diagnostic Laboratory, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Bedard","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, Large Animal Internal Medicine Service, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Czerwinski","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Paige","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2018.02.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000873"},{"key":"3","first-page":"205","article-title":"An apparently new transmissible disease of cattle","volume":"36","author":"P. Olafson","year":"1946","journal-title":"The Cornell Veterinarian"},{"issue":"2","key":"4","first-page":"117","article-title":"Multiple diagnostic tests to identify cattle with Bovine viral diarrhea virus and duration of positive test results in persistently infected cattle","volume":"73","author":"R. W. 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